Epidemiological Features and Phylogeny of SARS-CoV-2 Circulating in the Southeast Asia in Early Pandemic

Authors : Oktaviani Naulita TURNIP, Chairunnisa FADHİLLAH, Anwar ROVIK, Ayu RAHAYU

Pages : 139-147

Doi:10.5799/jmid.1218631

View : 8 | Download : 3

Publication Date : 2022-12-15

Article Type : Research Paper

Abstract :Objectives: This study aims to understand the epidemiological and level of genetic similarity in the SARS-CoV-2 from different geographical areas in The Southeast Asia Region during an early pandemic. Methods: The data on COVID-19 cases in Southeast Asia was collected from https://worldometer.info/ and extracted independently. Complete genome SARS-CoV-2 nucleotide sequence data was obtained from GISAID and NCBI online platforms. The sequences were aligned using MEGA X software and identified RdRp and Spike genes using UGENE software. The phylogenetic was constructed using MEGA X software to know the similarity of these genes among isolates in the Southeast Asia region. Results: The result showed that the first case in Southeast Asia was reported in January 2020. The highest number of COVID-19 cases and death were reported from populous and suffering countries. The phylogenetic results showed an identical solid insert ignore into journalissuearticles values(100%); among isolates, except for the Philippines-5 isolate. The Wuhan-Hu-1 insert ignore into journalissuearticles values(China); SARS-CoV-2 isolate insert ignore into journalissuearticles values(Acc. NC_045512); was transmitted to other countries in Southeast Asia regions with various mutations in the spike protein. Conclusion: During the early pandemic, all countries in the Southeast Asia regions reported COVID-19 cases. Indonesia became the country with the highest number of COVID-19 cases and deaths. The level of similarity of the RdRp gene in the SARS-CoV-2 in Southeast Asia is higher than the Spike genes. J Microbiol Infect Dis 2022; 12insert ignore into journalissuearticles values(4);:139-148.
Keywords : Epidemiology, Phylogeny, SARS Cov 2, Pandemic