Evaluation of Antibody Levels After Vaccination (Sinovac-CoronaVac) in Healthcare Workers

Authors : Hatice ERDOGAN, Filiz PEHLİVANOGLU, Gönül SENGÖZ, Feride VELAEİ

Pages : 154-159

Doi:10.5799/jmid.1218640

View : 8 | Download : 3

Publication Date : 2022-12-15

Article Type : Research Paper

Abstract :Objectives: This study aims to evaluate the effectiveness of the inactivated SARS-COV-2 vaccine insert ignore into journalissuearticles values(Sinovac-CoronaVac);, first administered to healthcare professionals in Turkey on January 14, 2021. Methods: Healthcare professionals without a history of COVID-19, PCR test positivity, or chronic disease were included in the study. The antibody levels for S1 RBD antigen were measured with the Siemens SARS-CoV-2 IgG insert ignore into journalissuearticles values(sCOVG); kit one month and six months after the two-dose CoronaVac vaccine. Results: A total of 108 health professionals, 35 women and 73 men, were included in this study. The mean age of the participants was 37.5 ± 10.7 years. A total of 103 insert ignore into journalissuearticles values(95.3%); individuals had positive antibody values, and five insert ignore into journalissuearticles values(4.6%); had negative values after the second vaccination. After the second vaccine dose, 11 insert ignore into journalissuearticles values(10.1%); participants were diagnosed with COVID-19. There was a significant decrease in antibody values in the sixth month compared to the first month insert ignore into journalissuearticles values(p <0.001);. The first-month measurements showed a significant negative correlation between age and antibody levels. Likewise, there were no significant differences in antibody levels between men and women in the first and sixth months. However, there was a significant difference in antibody levels in the first month for occupational groups insert ignore into journalissuearticles values(p=0.015);. The nurses\` antibody levels in the first month were significantly higher than the doctors insert ignore into journalissuearticles values(p=0.05);. Conclusion: Although the antibody level of the CoronaVac vaccine decreased significantly for the first six months, the infection was mild in 10 % of the participants. Large-scale studies are needed for the protectiveness of vaccines and the prevention of COVID-19. J Microbiol Infect Dis 2022; 12insert ignore into journalissuearticles values(4);:154-159.
Keywords : COVID 19, healthcare professionals, vaccination