The relationship between Helicobacter pylori and DNA hypermethylation in gastric cancer

Authors : Ayşe Nursal

Pages : 187-190

Doi:10.5799/ahinjs.02.2015.04.0204

View : 8 | Download : 3

Publication Date : 2016-02-06

Article Type : Review Paper

Abstract :Gastric cancer insert ignore into journalissuearticles values(GC); is one of the most common types of cancer across the world. GC carcinogenesis demonstrates a multi-step progression with the accumulation of genetic and epigenetic changes. The genetic changes on gene expression, without any change on deoxyribonucleic acid insert ignore into journalissuearticles values(DNA); sequencing, are named as “epigenetic”. DNA methylation is the most commonly studied epigenetic modification in mammalians. Hypermethylation is observed on CpG insert ignore into journalissuearticles values(—C— phosphate—G—); islands In GC, promoter regions of genes. This is a significant mechanism that causes functional losses in tumor suppressor genes. In gastric cancer, DNA hypermethylation is seen in many genes. Helicobacter pylori insert ignore into journalissuearticles values(H. pylori); are a type of spiral-shaped Gram-negative bacteria. It infects approximately half of the world’s population. H. pylori is an important etiological factor that causes GC in human beings. Chronic H. pylori infection in human is associated with hypermethylation of promoter sequences of different genes. This paper provides a review of the current literature on the relationship between H. pylori infection and DNA hypermethylation in GC. J Microbiol Infect Dis 2015;5insert ignore into journalissuearticles values(4);: 187-190 Key words: Gastric cancer, Helicobacter pylori, DNA hypermethylation.
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