Could High-Density Lipoprotein (HDL) Alone be a Predictive Biomarker for Patients with Erectile Dysfunction?

Authors : Abdullah Akkurt, Ercan Kazan, Cemal Nas

Pages : 1-10

Doi:10.58770/joinihp.1435248

View : 87 | Download : 55

Publication Date : 2024-03-28

Article Type : Research Paper

Abstract :This study aimed to assess High-Density Lipoprotein (HDL) levels as a predictor of ED in 105 men aged 20-60, to determine whether HDL levels alone could indicate Erectile Dysfunction (ED) risk independently of other factors. Despite the numerous cardiovascular risk factors associated with ED, this study uniquely focused on the predictive value of HDL levels, aiming to highlight its standalone significance in ED risk assessment. The study analyzed the interaction of HDL levels with variables such as BMI and smoking status to improve understanding of lipid profiles in assessing and managing ED Logistic regression was conducted to assess the link between low HDL levels (<40 mg/dL) and ED, while adjusting for confounding factors like age, BMI, smoking, and hypertension. The ROC curve analysis determined the optimal cutoff point for predicting ED using HDL levels. Patients with ED had significantly lower mean high-density lipoprotein (HDL) levels at 32.0 ± 10.9 mg/dL compared to the normal population’s 48.3 ± 12.1 mg/dL (p = 0.043). In the ED group, 66.67% of patients had HDL levels below 40 mg/dL, which was higher than the 41.39% observed in the normal population (p = 0.023). Additionally, the ED population had a higher mean BMI of 27.4 ± 4.6 kg/m² compared to 24.0 ± 5.2 kg/m² in the normal population (p = 0.011). Smoking was also more prevalent among ED patients, with 53.33% being current smokers compared to 35.23% in the normal population (p = 0.037). Subgroup analyses revealed an interaction between low HDL and smoking (B = 0.45, β = 0.30, p = 0.001), as well as between low HDL and BMI (B = 0.50, β = 0.35, p = 0.001), indicating that these combinations exacerbated ED risk more than any individual factor. Our research suggests that HDL could function as a useful predictive biomarker for ED. Clinicians should consider evaluating the HDL levels of patients with ED and potentially managing low HDL levels to alleviate ED symptoms.
Keywords : Erektil disfonksiyon, yüksek yoğunluklu lipoprotein, HDL, biyobelirteç, kardiyovasküler risk faktörleri, dislipidemi