A Theoretical Analysis of Malignant Tumor Growth Dynamics via the Hahnfeldt Equation Using Maple

Authors : Engin Can

Pages : 1-10

Doi:10.58770/joinihp.1586872

View : 16 | Download : 16

Publication Date : 2025-03-27

Article Type : Research Paper

Abstract :This study offers a comprehensive theoretical analysis of malignant tumor growth dynamics through the Hahnfeldt equation, a fundamental mathematical model in the field of mathematical oncology. The Hahnfeldt equation integrates essential biological processes such as angiogenesis, vascular support, and tumor growth inhibition, establishing a comprehensive framework for the analysis of tumor progression and regression. This research utilizes Maple\\\'s symbolic computation and numerical simulation capabilities to investigate the equation\\\'s behavior across different biological and therapeutic parameters. The study primarily analyzes key parameters, including angiogenic stimulation rates, carrying capacity, and inhibitory factors. We analyze the stability of equilibrium points to determine the impact of parameter variations on tumor growth trajectories. Bifurcation analysis identifies conditions under which small variations in parameters lead to substantial alterations in tumor dynamics, including uncontrolled growth, stable states, or regression. The findings offer significant insights into the non-linear and dynamic characteristics of tumor progression. Using Maple’s advanced visualization tools, the study presents graphical representations of tumor size evolution over time, highlighting the impact of different parameter sets. The study also investigates the impact of anti-angiogenic therapies through simulations of their effects on tumor dynamics. This analysis illustrates the efficacy of targeted therapeutic interventions in suppressing tumor growth or stabilizing its progression, providing potential strategies for enhancing cancer treatment. The study examines the limitations of the Hahnfeldt model and suggests potential extensions to improve its applicability in complex biological systems. The extensions involve integrating patient-specific data and linking the model with additional biological processes, including immune responses and drug resistance mechanisms. This research offers a comprehensive mathematical and computational analysis of the Hahnfeldt equation, highlighting its importance in the study of tumor growth and the development of precision medicine strategies. The findings seek to connect theoretical modeling with practical oncology applications, thereby advancing mathematical oncology and optimizing cancer therapy.
Keywords : Tümör büyümesi, bilgisayarlı onkoloji, Hahnfeldt denklemi, matematiksel modelleme, Maple.