Predictive value of c-reactive protein to albumin ratio and systemic immune-inflammation index for the long-term mortality in COVID-19

Authors : Esra POLAT, Cengiz ŞABANOĞLU, Muhdedir CANER, Fatma Yekta URKMEZ, Fulden AKYÜZ İNANÇ, Ünal ÖZTÜRK, Hüseyin KANDEMİR, Gamze Yeter ARSLAN, Elif İlkay YÜCE, İbrahim Halil İNANÇ

Pages : 126-132

Doi:10.47582/jompac.1256098

View : 18 | Download : 15

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Several studies have investigated the association between biomarkers and short-term prognosis in the coronavirus infectious disease 2019 insert ignore into journalissuearticles values(COVID-19);. However, data on the long-term prognosis are limited. To determine the predictive value of systemic immune-inflammation index insert ignore into journalissuearticles values(SII); and C-reactive protein insert ignore into journalissuearticles values(CRP); to albumin ratio insert ignore into journalissuearticles values(CAR); for in-hospital and 1-year outcomes during COVID-19. Material and Method: The primary outcomes were in-hospital and 1-year mortality. The secondary outcomes were the intensive care unit insert ignore into journalissuearticles values(ICU); need at admission and transfer to the ICU later on. Results: The study included 449 insert ignore into journalissuearticles values(53.6%); males and 389 insert ignore into journalissuearticles values(46.4%); females with a mean age of 53.8±18.5 years. Previously known heart failure insert ignore into journalissuearticles values(HF);, COVID-19-related HF, acute renal failure insert ignore into journalissuearticles values(ARF);, diabetes mellitus, hypertension, coronary artery disease insert ignore into journalissuearticles values(CAD);, chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD);/asthma, high CO-RADS scores insert ignore into journalissuearticles values(>4);, low ejection fraction insert ignore into journalissuearticles values(EF);, higher CAR and SII were associated with an increased in-hospital and 1-year mortality insert ignore into journalissuearticles values(p<0.05);. After multivariate analysis; CAR, SII, ARF, and diabetes mellitus were independent predictors of in-hospital and 1-year mortality,whereas CAD was only an independent predictor of 1-year mortality. After ROC analysis, CAR cut-off levels of 2.54 and 2.23 predicted in-hospital and 1-year mortality, respectively insert ignore into journalissuearticles values(p<0.001);. The SII cut-off levels of 1274 and 1191 predicted in-hospital and 1-year mortality, respectively insert ignore into journalissuearticles values(p<0.001);. Conclusion: CAR and SII can be used as valuable prognostic indexes to predict both the short-term and long-term mortality in COVID-19.
Keywords : Sistemik İmmün İnflamasyon İndeksi, SII, C reaktif protein albümin oranı, CAR, Uzun dönem mortalite, COVID 19