A novel inflammation indicator of acute stent thrombosis and in-hospital mortality in acute coronary syndrome: multiple inflammation index

Authors : Birsen DOĞANAY, Ozlem OZCAN CELEBİ

Pages : 168-175

Doi:10.47582/jompac.1256573

View : 14 | Download : 11

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: The inflammatory milieu plays a triggering role in the development of acute stent thrombosis insert ignore into journalissuearticles values(ST);, which occurs as a catastrophic complication following percutaneous coronary intervention insert ignore into journalissuearticles values(PCI); in patients with acute coronary syndrome insert ignore into journalissuearticles values(ACS);. This study aimed to investigate the prognostic role of multi-inflammatory index insert ignore into journalissuearticles values(MII);, a powerful new marker of inflammation, in predicting of high SYNTAX score, acute ST and in-hospital mortality in patients with ACS undergoing PCI. Material and Method: This retrospective study included 1488 consecutive patients with ACS undergoing PCI, and definitive ST was determined according to Academic Research Consortium criteria. Inflammation indices were calculated as follows: Systemic immune inflammation insert ignore into journalissuearticles values(SII);=neutrophil×platelet/lymphocyte ratio, CAR=CRP/albumin ratio, MII-1=platelet×CRP/lymphocyte ratio, MII-2=neutrophil×CRP/lymphocyte ratio, MII-3=SII×CRP. Results: The incidence of acute ST was 3.6%. All inflammation indices was higher in the acute ST group and high SYNTAX score group. Multivariable regression analysis showed that MII-3 independent predictors of acute ST and high SYNTAX score. MII-3 exhibited better diagnostic performance than other inflammatory indices. The threshold value of MII-3 in predicting acute ST was >9084 insert ignore into journalissuearticles values(AUC=0.842, sensitivity=87.3%, specificity=%77.8); and patients with MII-3 >9084 had a 3.73-fold greater risk of mortality. Conclusion: MII-3 is a stronger predictor of acute ST following PCI and it is associated with an increased risk of mortality. MII may be an essential prognostic screening tool for identifying high-risk patients prior to procedure.
Keywords : Akut koroner sendrom, inflamasyon, stent trombozu, SYNTAX skoru