Are the correlation results of HPV positive cases with cervical smear always consistent?

Authors : Sema ZERGEROĞLU, Zehra Sema ÖZKAN, Arzu Hazal AYDIN

Pages : 158-162

Doi:10.47582/jompac.1258024

View : 19 | Download : 8

Publication Date : 2023-03-27

Article Type : Research Paper

Abstract :Aim: Cervical cancer is a type of genital cancer which come second after breast cancer in women and may cause death. However, it can be prevented with screening tests by ensuring early diagnosis. Most of cervical cancers insert ignore into journalissuearticles values(99.7%); are associated with Human Papilloma Virus insert ignore into journalissuearticles values(HPV); and it is known that HPV must be present for the generation of cervical cancer. Thus, 70% of the patients have been found to be positive for HPV-16 and HPV-18. Both the association with cervical cancer and HPV and data related to development of cancer and dysplasia was researched retrospectively in this study. It was aimed to analyze and use the results by examine if the smear results of the patients and the HPV results are compatible in all HPV positive cases. Material and Method: 1050 patients who were examined by gynecologist and taken Pap smear test at the end of the examination during July 2020 and March 2022, were included in our study. In all cases the Pap test was re-evaluated by the same pathologist using the 2014 Bethesda System. High-risk HPV insert ignore into journalissuearticles values(HR HPV); DNA insert ignore into journalissuearticles values(HPV types 16,18,31,33,35,39,45,51,52,56,58,59,66,68); tests results, applied to the patients at an external center, were reviewed. Results of patients diagnosed as LSIL, HSIL and cervical cancer by Pap smear test were evaluated again beside HPV DNA analyses and their clinical information. Chi-square test was used for statistical analysis. p<0.05 values were considered statistically significant. Results: Of 1050 patients, 139 had LSIL, 170 had HSIL, and 112 had cervical cancer. The highest incidence of LSIL, HSIL and cancer was observed in the 30-39 age group, while the rate of these diseases was lower in the 50-59 age group compared to other groups. In addition, all patients with SIL and cervical cancer had smoking history. HR HPV DNA test was positive in 240 of 1050 patients. 56 patients diagnosed as LSIL and 89 patients diagnosed as HSIL by Pap smear had positive HR HPV DNA test results. HR HPV DNA positivity was reported in 74 of 112 patients with cervical cancer. In 21 patients who had normal smear test were detected HR HPV DNA positivity. 17 of these patients were in the 30-39 age group and 4 of them were in the 40-49 age group. Conclusions: Because of all 112 patients with cancer were not HR HPV positive and the smear results of 21 HR HPV positive patients were normal, our study serves an example for studies to show that the results of smear and HPV DNA in cervical cancer are not always compatible.
Keywords : serviks, kanser, HPV, tarama