Evaluation of the relationship between insulin resistance and different phenotypes of polycystic ovary syndrome

Authors : Mehmet AĞAR, Murat ÖNAL, Halime ÇALI ÖZTÜRK

Pages : 183-188

View : 44 | Download : 42

Publication Date : 2023-06-28

Article Type : Research Paper

Abstract :Aims: Polycystic ovary syndrome insert ignore into journalissuearticles values(PCOS); is a common endocrine disorder in women. Hyperinsulinemia and insulin resistance insert ignore into journalissuearticles values(IR); are the most important metabolic abnormalities that affect these patients. This study aimed to investigate the variables related to IR in patients with different PCOS phenotypes. Methods: This retrospective study included 389 women diagnosed with PCOS in Bezmialem Hospital between november 2020 and september 2022. Information about patients was collected through their electronic records. PCOS was diagnosed based on the Rotterdam criteria, and four phenotypes of A insert ignore into journalissuearticles values(oligoovulation+ hyperandrogenism+PCO);, B insert ignore into journalissuearticles values(oligoovulation+hyperandrogenism);, C insert ignore into journalissuearticles values(hyperandrogenism +PCO);, and D insert ignore into journalissuearticles values(oligoovulation+absent PCO); were considered for PCOS. The homeostatic model assessment for ınsulin resistance insert ignore into journalissuearticles values(HOMA-IR); was used to evaluate IR. The Mann-Whitney U test was performed to study the difference between the groups. Results: The highest value of HOMA-IR was for the phenotype B group, and the lowest value was for the phenotype C group. However, the difference between the groups was not significant insert ignore into journalissuearticles values(p=0.221);. Estradiol and free T4 were significantly higher in the phenotype A group insert ignore into journalissuearticles values(p≤0.001);. Thyroid-stimulating hormone insert ignore into journalissuearticles values(TSH);, prolactin, anti-mullerian hormone insert ignore into journalissuearticles values(AMH);, fasting insulin, total testosterone, and red blood cell distribution width insert ignore into journalissuearticles values(RDW); were significantly higher in the phenotype B group insert ignore into journalissuearticles values(p≤0.001);. Total cholesterol, high density lipoprotein insert ignore into journalissuearticles values(HDL);, leukocyte, basophil, and monocyte were significantly higher in the phenotype C group insert ignore into journalissuearticles values(p≤0.001);. Also, MPV values were significantly higher in the phenotype D group insert ignore into journalissuearticles values(p≤0.001);. Conclusion: The results showed that the variables related to IR in phenotypes A and B of PCOS are higher than in other phenotypes.
Keywords : Polycystic Ovary Syndrome, insulin resistance, HOMA IR, RDW