Increased frequency of hypertension and coronary artery disease independent of age in primary hyperparathyroidism associated hypercalcaemia

Authors : Elif GÜNEŞ, Mutlu GÜNEŞ

Pages : 277-282

Doi:10.47582/jompac.1324604

View : 69 | Download : 60

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Aims: There are conflicting data in the literature regarding whether there is an increased frequency of coronary artery disease insert ignore into journalissuearticles values(CAD); in patients with primary hyperparathyroidism insert ignore into journalissuearticles values(PHP);. In this study, we planned to investigate the frequency of CAD and hypertension insert ignore into journalissuearticles values(HT); in patients with PHP. Methods: Patients with PHP aged 18 years and older who were admitted to the endocrinology clinic between September 2020 and February 2023 were included as the patient group, and age- and gender-matched individuals who presented with thyroid nodules between the same dates were included as the control group. A total of 217 patients, 114 with PHP and 103 as control group, were eligible for the study. The study was conducted as a retrospective data analysis and laboratory and demographic information of the patients and the control group were obtained from their files. Results: Age and gender distribution of the patient group and the control group were similar insert ignore into journalissuearticles values(respectively; age: 55.6+12.9 years, 53.0+7.2 years, p=0.058, female/male distribution: 93/21, 80/23 p=0.48);. The prevalence of HT and CAD was higher in the patient group insert ignore into journalissuearticles values(respectively; HT: 65.1%, 31.0%, p<0.001, CAD: 32.0%, 3.1%, p<0.001);, while the prevalence of DM was similar insert ignore into journalissuearticles values(respectively; 18.1%, 17.3%, p=0.89);. The prevalence of HT, CAD and DM was found to be the same among those with mild and severe PHP insert ignore into journalissuearticles values(respectively; HT: 65.6%, 64.4%, p=0.90, CAD: 38.3%, 23.3%, p=0.14, DM: 19.7%, 15.9%, p=0.62, );. Age insert ignore into journalissuearticles values(β=0.10, odds ratio [OR];1.11 [95% confidence interval insert ignore into journalissuearticles values(95% CI);;1.05-1.17], p<0.001); and calcium insert ignore into journalissuearticles values(β=0.67, OR;1.96 [95% CI;1.10-3.51], p=0.023); levels were found to be independent effective factors on CAD. Conclusion: Increased calcium levels in PHP constitute an age-independent risk for CAD. In addition, elevated calcium increases the frequency of HT, which is a CAD risk factor.
Keywords : Primer hiperparatiroidi, hipertansiyon, koroner arter hastalığı, hiperkalsemi

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