Evaluation of clopidogrel use on gastric precancerous lesions: Does it have chemopreventive effect?

Authors : Taner Akyol

Pages : 524-529

Doi:10.47582/jompac.1352478

View : 69 | Download : 109

Publication Date : 2023-10-27

Article Type : Research Paper

Abstract :Aims: Gastric malignancies are the third most common cause of cancer-related deaths. Although aspirin and clopidogrel have been reported to reduce the risk of colorectal cancer, their effects on gastric cancer are still under investigation. In this study, we aimed to determine whether clopidogrel has an effect on the development of gastric precancerous lesions. Methods: The study was designed as a retrospective case-control study. The study was conducted between January 2021 and April 2023 in the Gastroenterology Clinic of Samsun University Samsun Training and Research Hospital. Patients who underwent upper GIS endoscopy and biopsy examination due to dyspeptic complaints were scanned from the electronic data system of the hospital and their data were recorded by forming 4 groups as clopidogrel (89 patients), low-dose aspirin (ASA) (172 patients), non-aspirin non-steroidal anti-inflammatory drug (NA-NSAID) users (110 patients) and control group without antiplatelet use (110 patients). Statistical analyses were accomplished with SPSS for Windows v20.0. Results: Mean duration of drug use was 2 years for clopidogrel, 1.47 years for ASA and 0.35 years for NA-NSAID. The incidence of peptic ulcer was 7.2% in the control group, 38%, 15.1%, 49% in clopidogrel, ASA, NA-NSAID users, respectively (p<0.001). The frequency of H. pylori infection in the groups was 61%, 53.5%, 40.1%, 46.1%, respectively. There was a significant difference between ASA and control group (p<0.001). Intestinal metaplasia was observed in 23.1%, 29.5%, 31.2%, 23.1%, respectively (p=0.291). Atrophic gastritis was 16.6%, 35.2%, 19.2%, 29.3%, respectively (p=0.003). No difference was observed between the groups in terms of dysplasia, gastric cancer and esophageal cancer. Conclusion: According to our results, no preventive effects of clopidogrel, ASA and NA-NSAID use on precancerous lesions or gastric cancer development were observed. However, the use of these drugs was associated with severe gastroduodenal lesions.
Keywords : Anahtar Kelimeler Aspirin, Klopidogrel, mide kanseri, mide kanserli lezyonlar