Experimental study: effects of folic acid, vitamin C, and vitamin E on fat graft survival

Authors : Mehmet Fatih Okyay

Pages : 561-565

Doi:10.47582/jompac.1359372

View : 109 | Download : 138

Publication Date : 2023-10-27

Article Type : Research Paper

Abstract :Aim: This study explores the potential of folic acid (vitamin B9), ascorbic acid (vitamin C), and α-tocopherol (vitamin E) to enhance fat graft survival. Material and Method: The dorsal regions of the Sprague-Dawley rats (n=10) were divided into four quadrants as inguinal fat donor recipient sites. After incubation, fat grafts were placed into sites (0.9% NaCl-left cranial, vitamin B9-right cranial, vitamin C-left caudal, and vitamin E-right caudal). At the end of the third month, fat grafts were harvested. Fat grafts were evaluated immunohistochemically with perilipin to reveal viability. Results: Folic acid, vitamin C, and vitamin E were shown improved fat graft survival rate with perilipin (p<0.001, p<0.001, p<0.001, respectively). Conclusion: Effects of folic acid (vitamin B9) in promoting angiogenesis and collagen synthesis, vitamin C\'s antioxidant properties and involvement in collagen synthesis, vitamin E’s potent antioxidant capacity, appeared to protect grafted adipose tissue from oxidative stress and inflammation, facilitates graft vascularization and integration, leading to enhanced survival. As an inexpensive and easy-to-supply and apply agents, vitamins B9, C, and E were found to improve fat graft survival immunohistochemically in our study. Increased graft viability by these medicines may inspire future clinical studies and practice.
Keywords : adipogenesis, ascorbic acid, fat graft survival, folic acid, vitamin C, vitamin E