Synthesis of Chlorotoxin by Native Chemical Ligation

Authors : Yuvaraj TCM, Parameshwara Naik P, Venkatesh T V, Krishnamurthy G, Manjuraj T

Pages : 845-856

Doi:10.18596/jotcsa.341379

View : 14 | Download : 11

Publication Date : 2018-01-01

Article Type : Research Paper

Abstract :A series of Mninsert ignore into journalissuearticles values(II);, Coinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);, Cuinsert ignore into journalissuearticles values(II); and Zninsert ignore into journalissuearticles values(II); metal complexes are derived from ligand insert ignore into journalissuearticles values(N-insert ignore into journalissuearticles values(3-methoxyphenyl);-2-[insert ignore into journalissuearticles values(2E);-3-phenylprop-2-enoyl]hydrazinecarboxamide[MPH], and structurally characterized by various physicochemical and spectral tools such as IR, UV-Visible, 1H-NMR, LC-Mass, powder XRD and TGA-DTC.These studies showed that the ligand coordinated to the metal atom in a bidentate manner and have octahedral environment.X-ray diffraction studies indicates that the Coinsert ignore into journalissuearticles values(II); and Cuinsert ignore into journalissuearticles values(II); complexes are Crystalline in nature, Degradation mechanism, kinetic and thermodynamic parameters of the synthesized metal complexes has been evaluated.The synthesized compounds were evaluated for in vitroantioxidant DPPH assay, in which metal complexes showed excellent activity. The molecular docking analysis by using human antioxidant enzyme DTT insert ignore into journalissuearticles values(PDB: 3MNG);have also been evaluated. The ligand and their metal complexes were screened for their antifungal and antibacterial activities against different species of pathogenic fungi and bacteria.
Keywords : Semicarbazide, Metal complexes Powder XRD, TGA, antioxidant