Investigation of singlet oxygen production property of peripherally tetra-substituted In(III)CI phthalocyanine for photodynamic therapy

Authors : Semih GÖRDÜK

Pages : 279-288

Doi:10.18596/jotcsa.812081

View : 22 | Download : 7

Publication Date : 2021-02-28

Article Type : Research Paper

Abstract :Phthalocyanines insert ignore into journalissuearticles values(Pcs); are macrocyclic compounds of great importance. Different metals and ligands can be used in the synthesis of Pc compounds and it seems interesting that these give different properties to Pcs. Thus, the usage areas of Pcs have been increasing day by day. One of the most important areas of use of Pcs is photodynamic therapy insert ignore into journalissuearticles values(PDT); application. The scope of this study is synthesis, characterization and investigation of singlet oxygen generation property of new peripherally tetra benzodioxane substituted indiuminsert ignore into journalissuearticles values(III); chloro phthalocyanine insert ignore into journalissuearticles values(InCIPc); which may be used as a potential photosensitizer for photodynamic therapy insert ignore into journalissuearticles values(PDT); applications. The new compound was characterized by various techniques such as elemental analysis, FT-IR, 1H NMR, MS, and UV–Vis techniques. Furthermore, photophysical and photochemical properties of newly synthesized Pc were investigated for PDT studies. At the same time, the effect of combination of heavy indium atom and benzodioxane groups bearing oxygen atom on solubility and photophysicochemical properties was discussed. The results showed that this compound exhibits good solubility in DMSO and shows high singlet oxygen production. According to the displayed properties and singlet oxygen production, we can say that this compound is a potential candidate for PDT applications.
Keywords : Photodynamic therapy, Phthalocyanine, singlet oxygen, Indium III, metal ion, Photophysicochemical