Novel Functional Axially Substituted Silicon (IV) Phthalocyanine Derivative and its Photochemical Properties

Authors : Hülya YANIK, Gülçin EKİNEKER

Pages : 545-552

Doi:10.18596/jotcsa.995902

View : 14 | Download : 6

Publication Date : 2022-05-31

Article Type : Research Paper

Abstract :Photodynamic therapy is a highly specific and clinically approved method in which a non-toxic photosensitizer drug is administered to the patient for cancer treatment. Phthalocyanines with their long wavelength absorption and fluorescence from 650 to 800 nm can be used as photosensitizers for photodynamic therapy and are used in clinical trials. In this study, functional novel axially substituted silicon insert ignore into journalissuearticles values(IV); phthalocyanine insert ignore into journalissuearticles values(PS-2); was synthesized. Unsubstituted dichlorosilicon insert ignore into journalissuearticles values(IV); phthalocyanine was synthesized from 1,3-diiminoisoindoline via cyclotetramerization. The axial substitution reaction was carried out using dichlorosilicon insert ignore into journalissuearticles values(IV); phthalocyanine and excess of N-Boc-ethanolamine. Structural characterization of this novel PS-2 by FT-IR, mass, 1H NMR and UV-Vis spectroscopy were performed. Photochemical properties insert ignore into journalissuearticles values(photo degradation quantum yields insert ignore into journalissuearticles values(d); and singlet oxygen quantum yield insert ignore into journalissuearticles values(); of PS-2, which are the first steps for cancer treatment, were investigated.
Keywords : Photodynamic therapy, Singlet Oxygen Quantum Yield, Silicon IV, Phthalocyanine