Ameliorative Effects of Vanadyl Sulfate on Some Biochemical Parameters of Experimental Diabetic Rat Kidneys

Authors : Nurdagül ORHAN, Sevim TUNALI, Refiye YANARDAĞ

Pages : 721-728

Doi:10.18596/jotcsa.1071151

View : 15 | Download : 10

Publication Date : 2022-08-31

Article Type : Research Paper

Abstract :    Diabetes mellitus insert ignore into journalissuearticles values(DM);, closely related to diabetic nephropathy, is one of the major public health problems worldwide. Today, with the increasing understanding of the underlying pathophysiology of DM, new oral anti-diabetic treatment strategies are being developed. Vanadium is a transition element that is widely distributed in nature, and its oral administration has been reported to improve DM in humans and a variety of diabetic animal models. The purpose of the research is to explore the effect of vanadyl sulfate insert ignore into journalissuearticles values(VS); administration on the different enzyme activities associated with kidney injury in streptozotocin- insert ignore into journalissuearticles values(STZ); induced diabetic rats. Male rats were assigned into groups as follows: untreated control, control animals given VS insert ignore into journalissuearticles values(100 mg/kg);, diabetic insert ignore into journalissuearticles values(a single dose of intraperitoneal STZ, 65 mg/kg);, and diabetic + VS insert ignore into journalissuearticles values(same dose); group. VS was administered orally for 60 days after the induction of diabetes. On the 60th day of experiment, kidney samples were taken for analysis. According to the data obtained from the biochemical analysis, the activities of transaminases, alkaline phosphatase, carbonic anhydrase, and γ-glutamyl transpeptidase decreased, whereas superoxide dismutase activity elevated in the kidney tissue of VS treated hyperglycemic animals. The results suggested that VS improved the diabetic renal injury, probably by VS insulin-mimic and antioxidant behavior through decreased oxidative stress and increased antioxidant capacity. Therefore, vanadyl sulfate might be used as a potential oral anti-diabetic compound in the treatment of the diabetic nephropathy, and as an important control for elevated blood glucose levels in the diabetic state.
Keywords : Diabetes mellitus, vanadyl sulfate, kidney tissue, oxidative stress