Acetylcholinesterase Inhibition Properties and Docking Studies of Compounds Based on 6-Hydrazinyl-1,3,4-Trimethyl-1H-Pyrazolo[3,4-b]Pyridine

Authors : Seyit Ali GÜNGÖR

Pages : 21-30

Doi:10.18596/jotcsa.1117324

View : 14 | Download : 11

Publication Date : 2023-02-28

Article Type : Research Paper

Abstract :New compounds based on 6-hydrazinyl-1,3,4-trimethyl-1H-pyrazolo[3,4-b]pyridine insert ignore into journalissuearticles values(3a and 3b); were synthesized and characterized by FTIR and 1H/13C NMR spectroscopic methods and their in vitro acetylcholinesterase insert ignore into journalissuearticles values(AChE); inhibition studies were evaluated. Compound 3b insert ignore into journalissuearticles values(IC50 value 104.4 µM); exhibited stronger AChE inhibitory activity than the reference galantamine compound insert ignore into journalissuearticles values(IC50 value 139.4 µM);. Molecular docking studies were performed to determine the key interactions and possible binding modes between AChE of compounds. The most active one, 3b, showed a binding affinity of -10.28 kcal/mol.
Keywords : Synthesis, AChE inhibition, Docking