Design, Synthesis and Anti-Bacterial Activity Evaluation of Indole-Based Benzophenone and Their Derivatives

Authors : Fekadu Tumoro ERABE, Dagne Adisu KURE, Salah SHERİF

Pages : 653-658

Doi:10.18596/jotcsa.1235642

View : 38 | Download : 66

Publication Date : 2023-08-30

Article Type : Research Paper

Abstract :Indole and benzophenone moiety are of significant interest to investigators because they are found in many natural products and pharmacologically active compounds. They represent versatile synthetic building blocks. The benzophenone and indole scaffolds are special structures in medicinal chemistry because these compounds are found in several biologically active natural products, compounds containing indole and benzophenone exhibit anticancer, antiinflammatory, antimicrobial, and antiviral activities. In this study, derivatives of 2-insert ignore into journalissuearticles values(diphenyl methylene); hydrazine, containing both indole and benzophenone moieties were successfully synthesized. The structural elucidation of the synthesized compounds were done using spectroscopic techniques like IR, 1HNMR, and 13CNMR. The synthesized target compounds were investigated for their in vitro antibacterial activity against two bacterial strains; staphylococcus aureus insert ignore into journalissuearticles values(S. auras);, and Escherichia coli insert ignore into journalissuearticles values(E. coli); using the disc diffusion method. All synthesized target compounds showed no significant activity against Staphylococcus aureus insert ignore into journalissuearticles values(S. aureus); but exhibited moderate activity against Escherichia coli insert ignore into journalissuearticles values(E. coli);. Among all the synthesized compounds, 2-insert ignore into journalissuearticles values(diphenyl methylene);-1-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(1-tosyl-1H-indol-3-yl); methylene); hydrazine insert ignore into journalissuearticles values(BHT); insert ignore into journalissuearticles values(7b); showed a good inhibition at a concentration of 50 μg/mL with a zone of inhibition of 21.7 mm against Escherichia coli insert ignore into journalissuearticles values(E.coli); which was comparable with standard drug Ceftriaxone with the zone of inhibition of 26 mm. Thus, this compound could be considered as a lead molecule to design and develop novel antibacterial drugs.
Keywords : Staphylococcus aureus and Escherichia coli, Staphylococcus aureus and Escherichia coli, Staphylococcus aureus and Escherichia coli, Escherichia coli, Staphylococcus aureus