Effect of Intravenously Injected Arachidonic Acid on Electrocardiography in Rats

Authors : Esra KAŞIKÇI, Murat YALÇIN

Pages : 62-66

Doi:10.30782/jrvm.1124608

View : 14 | Download : 12

Publication Date : 2022-12-31

Article Type : Research Paper

Abstract :Arachidonic acid insert ignore into journalissuearticles values(AA);, which is released from phospholipids in the cell membrane by a variety of stimuli, has physiological and pathophysiological roles on the cardiovascular system. The current study designed to determine the effect of intravenously insert ignore into journalissuearticles values(iv); injected AA on the electrocardiography insert ignore into journalissuearticles values(ECG); of the anesthetized rats. The ECG waves obtained from the lead II were written by placing electrodes to limbs of the ketamine and xylazine mixture insert ignore into journalissuearticles values(50 mg/kg/20 mg/kg; im); anesthetized adult Spraque Dawley rats. AA insert ignore into journalissuearticles values(3 mg/kg; iv); statistically significantly insert ignore into journalissuearticles values(p<0.05); caused to prolong of the ECG waves and intervals resulting in a decrease in the heart rate of the rats. The current findings herein present the effect of the most abundant endogenous unsaturated fatty acid AA on ECG. The results clearly showed that AA could produce to bradycardia response by increasing the ECG waves and interval durations.
Keywords : Arachidonic acid, Electrocardiography, Intravenous, Heart rate