pH-RESPONSIVE CARBOXYMETHYL CELLULOSE CONJUGATED SUPERPARAMAGNETIC IRON OXIDE NANOCARRIERS

Authors : Tülin GÜRKAN POLAT, Seda DEMİREL TOPEL

Pages : 99-110

Doi:10.26900/jsp.3.011

View : 7 | Download : 3

Publication Date : 2019-04-30

Article Type : Research Paper

Abstract :In the present study, polyethyleneimine insert ignore into journalissuearticles values(PEI); coated superparamagnetic iron oxide nanoparticles insert ignore into journalissuearticles values(SPIONs); having the size of 15 nm in diameter with high magnetic saturation insert ignore into journalissuearticles values(60 emu/g); have been prepared by co-precipitation method. The synthesized PEI-Fe3O4 nanoparticles have been fully characterized by transmission electron microscope insert ignore into journalissuearticles values(TEM);, dynamic light scattering insert ignore into journalissuearticles values(DLS);, Fourier transform infrared insert ignore into journalissuearticles values(FTIR); spectroscopy, X-ray photoelectron spectroscopy insert ignore into journalissuearticles values(XPS); and X-ray diffraction insert ignore into journalissuearticles values(XRD); techniques. The free amine groups on the PEI-Fe3O4 surface has been covalently functionalized with carboxymethyl cellulose insert ignore into journalissuearticles values(CMC); by the catalysis of N,N`-Dicyclohexylcarbodiimide insert ignore into journalissuearticles values(DCC); and N, N`-Dimethylpyridin-4-amine insert ignore into journalissuearticles values(DMAP); coupling to produce CMC-Fe3O4 nanocarriers. The prepared CMC-Fe3O4 nanocarriers have been loaded with a well-known anti-tumor drug doxorubicin insert ignore into journalissuearticles values(Dox); and investigated its loading and releasing profiles from the nanocarrier. The CMC acted as an excellent nanocarrier for Dox with a loading efficiency ≈ 86%. The drug releasing profile has been studied at different pH values insert ignore into journalissuearticles values(3.5; 5.5; and 7.4);. When the pH of the release medium insert ignore into journalissuearticles values(phosphate buffer solution); was changed from 7.4 to 5.5 or 3.6, the drug release has been increased which indicates that the drug releasing is pH dependent.
Keywords : Superparamagnetic iron oxide, carboxymethyl cellulose, doxorubicin, pH, drug release