VOLTAMMETRIC AND CHROMATOGRAPHIC DETERMINATION OF NAPROXEN IN DRUG FORMULATION

Authors : Suzan Yanik YANIK, Selehattin YILMAZ, Gülsen SAGLIKOGLU, Murat SADIKOGLU, Özlem TONGUC YAYINTAS

Pages : 299-310

Doi:10.26900/jsp.3.031

View : 11 | Download : 2

Publication Date : 2019-10-29

Article Type : Research Paper

Abstract :In this work, the electrochemical oxidation of naproxen insert ignore into journalissuearticles values(NAP); was studied at an ultra-trace graphite electrode insert ignore into journalissuearticles values(UTGE);. The cyclic voltammetry insert ignore into journalissuearticles values(CV); technique was used to determine the optimum conditions and the effect of pH on the electrochemical oxidation of NAP. Acetate buffer insert ignore into journalissuearticles values(pH 4.50); was selected as the support electrolyte due to obtaining the highest electronic signal increase during oxidation of NAP at UTGE. The differential pulse voltammetry insert ignore into journalissuearticles values(DPV); technique was performed for electrochemical determination of NAP. In the optimum conditions, the limits of detection insert ignore into journalissuearticles values(LOD); and quantification insert ignore into journalissuearticles values(LOQ); were determined to be 8.6610-8 M and 2.8810-7 M. In addition, the amount of NAP was determined in drug tablets. The recovery studies of NAP from the drug tablet were completed in order to check the accuracy and precision of the applied voltammetric method. Furthermore, the determination of NAP was performed with the high-performance liquid chromatography insert ignore into journalissuearticles values(HPLC); method. These two methods were compared in terms of accuracy, precision and recovery studies.
Keywords : commercial drug tablets, naproxen, voltammetric method, differential pulse voltammetry, cyclic voltammetry, high performance liquid chromatography, ultra trace graphite electrode