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  • Journal of Experimental and Clinical Medicine
  • Volume:8 Issue:4
  • Ruhsal Hastalığı Olan Erkeklerde X-Kromotin Sıklığı

Ruhsal Hastalığı Olan Erkeklerde X-Kromotin Sıklığı

Authors : M ELBİSTAN, MN ALP, T BUDAK
Pages : 0-0
Doi:10.5835/jecm.v8i4.336
View : 34 | Download : 8
Publication Date : 2009-12-22
Article Type : Other Papers
Abstract :✓ The frequency of x-chromatin anomalies has been ivestigated in a total of 280 male patients admitted to Elazığ Psychiatric Hospital, with a diagnosis of schizophrenic in 205. Psychotic in 48 and oligophrenic in 17. X-chromaties of 24830 cells were examined after staining with guard dye. Chromosome analysis was carried out using lymphocyte tissue culture in x-chromatin positive or doubful cases. Only one patient had x-chromatin in schizophrenic group with a ratio of 38 % insert ignore into journalissuearticles values(Figure 1);. Chromosome analysis in this case showed a 47.XXY genotype insert ignore into journalissuearticles values(Klinefelter syndrome); insert ignore into journalissuearticles values(Figure 2);. The anomaly of x-chromatin hasn`t been observed in the other groups. In this study, it has been concluded that the grequency of x-chromatin anomaly was 0.5 % in schizophrenic group and 0.3% in all patients. ✓ Elazığ Ruh ve Sinir Hastalıkları Hastanesi`ne kabul edilen 205 şizofrenik, 48 psikotik, 17 oligofrenik olmak üzere toplam 280 erkek olguda x-kromatin anomali sıklığı araştırıldı. Guard yöntemi ile boyanmış ve olgulara ait 24830 hücrede x-kromatin analizi yapıldı. X-kromatini pozitif yada pozitif şüphesi veren olgularda lenfosit doku kültüründen kromozom analizi gerçekleştirildi. Analizler sonucunda sadece şizofrenik bir olgunun x-kromatini %38 oranında pozitif insert ignore into journalissuearticles values(Şekil 1);, genotipi ise 47.XXY insert ignore into journalissuearticles values(Klinefelter sendromu); insert ignore into journalissuearticles values(Şekil 2); olarak belirlendi. Diğer iki hasta gruplarında x-kromatin anomalisine rastlanmadı. Çalışmada x-kromatin anomali sıklığı tüm populasyonda % 0.3, şizofreniklerde ise % 0.5 oranında gerçekleşti.
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