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  • Journal of Experimental and Clinical Medicine
  • Volume:10 Issue:1-2
  • Tıp I Diabetes Mellitus’ta Preklinik Kardiyomiyopati

Tıp I Diabetes Mellitus’ta Preklinik Kardiyomiyopati

Authors : S ÖNELGE, K BAYSAL, N GÜRSES, S ACAR, Ş KÜÇÜKÖDÜK, S UYSAL
Pages : 0-0
Doi:10.5835/jecm.v10i1-2.459
View : 33 | Download : 9
Publication Date : 2009-12-22
Article Type : Other Papers
Abstract :Preclinic findings of Cardiomyopathy In Type I Diabetes Mellitus 39 asymptomatic, normotensive type I diabetic patients, aged 4-24 years, with no reti¬nopathy, proteinuria, normal screening tests and elektrocardiograms, and 39 healthy control subjects underwent M-mode echocardiography. Left ventricular end diastolic dimensions and volumes were found unchanged in type I diabetic patients compared to control subjects. Left ventricular posterior wall thickness insert ignore into journalissuearticles values(LVPW); interventiricular septum thickness insert ignore into journalissuearticles values(IVST);, left ventricular mass insert ignore into journalissuearticles values(LVM); and left ventricular mass index were sinificantly increased in the diabetics. The increase on the mass was symmetric, cardiac index insert ignore into journalissuearticles values(CI);, left ventricular ejection fraction insert ignore into journalissuearticles values(EF);, left ventricular shortening fraction insert ignore into journalissuearticles values(FS); and velocity of circumfrential fiber insert ignore into journalissuearticles values(Vcf); were signi¬ficantly lower in the diabetics. No correlation was found between HbAlc and cardiac functions. The duration of diabetes correlated with LVPW, IVST, LVM and inversely correlated with CI. These finding support the existance of a preclinic cardiomyopathy with left ventricular systolic dysfunction in type I diabetic patients in the early course of the disease. 4-24 yaşları arasında, asemptomatik, normotensif, retinopati ve proteinürisi olmayan, elektrokardiyografi ve kan biyokimya değerleri normal sınırlarda olan 39 tip I diabetli hasta ile sağlıklı kontrollerine M mode ekokardiyografi uygulandı. Tıp I diabetli olgularda sol ventrikül diyastol sonu çap ve volümleri kontrollere göre farksız olarak saptanırken; sol ventrikül arka duvar kalınlığı insert ignore into journalissuearticles values(SVADK);, interventriküler septum kalınlığı insert ignore into journalissuearticles values(IVSK);, sol ventrikül kütlesi insert ignore into journalissuearticles values(SVK); ve SVK indeksi önemli derecede yüksek bulundu. Kütle artışında asimetri olmadığı belirlendi. Kardiyak indeks insert ignore into journalissuearticles values(Ki);, ejeksiyon fraksiyonu insert ignore into journalissuearticles values(EF);, kısalma fraksiyonu insert ignore into journalissuearticles values(KF); ve çevresel lif kısalma hızı insert ignore into journalissuearticles values(VCF);`nin tip I diabetiklerde anlamlı ölçüde azaldığı saptandı. Kardiyak parametrelerle HbAlc arasında ilişki görülmezken; diabetin süresinin IVSK, SVADK ve SVK ile pozitif, KI ile negatif ilişki gösterdiği belirlendi. Çalışma sonuçlarımız tip I diabetes mellitusta erken dönemde sol ventrikül fonksiyon¬larında bozulma ile karakterli preklinik kardiyomiyopati geliştiğini göstermektedir.
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