The Effects Of Nimodipine, Tyrotyropine Releasing Hormon (TRH) And Gingkgo Biloba Extract (GBB) İn Experimental Spinal Cord Injuries

Authors : Ö İYİGÜN, N MERCAN, Z ŞEKERCİ, A ŞENEL, C ÇOKLUK, S BARIŞ, F ÇELİK, C RAKUNT

Pages : 0-0

Doi:10.5835/jecm.v11i2.525

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Publication Date : 2009-12-22

Article Type : Other Papers

Abstract :There have been interest in the role of some drugs in the pathohysiology of spinal cord in¬jury. In the present study we have evaluated the effects of treatment with nimodipine, TRH, GBE on functional recorvery and histopatological changes when these drugs are administered after spinal cord trauma in the anesthetized rabbits. 50 rabbits were divided in five treatment groups. Group 1 insert ignore into journalissuearticles values(10 Rabbits); received nimodipine insert ignore into journalissuearticles values(500 p:g/kg/day intraperitoneally); during first 7 days. Group 2 insert ignore into journalissuearticles values(10 Rabbits); receivied TRH insert ignore into journalissuearticles values(2,5 |ig/kg/day intraperitoneally); during first 7 day. Group 3 insert ignore into journalissuearticles values(10 Rabbits); received GBE insert ignore into journalissuearticles values(1 mgr/kg/day intra-peritoneally); during first 7 day. Group 4 insert ignore into journalissuearticles values(10 Rabbits); received nimodipine, TRH, GBE at the same time, during the first 7 days. Group 5insert ignore into journalissuearticles values(10 Rabbits); received no drug after spinal cord injury. There was no significant clinical and histopatological differences scores among the three treatment groups insert ignore into journalissuearticles values(Group 1, 2, 3); whereas Group 4 had better clinical scores than other groups. Deneysel Spinal Kord Yaralanmalarında Nimodipine, TRH ve Gingkgo Biloba Ekstresinin Etkileri %/ Spinal kord yaralanmalarının flzyopatolojisinde birçok ilacın önemli rolleri vardır. Bu çalışmada, anestezi altındaki tavşanlara spinal kord travması yaptıktan sonra Nimodipine, TRH ve Ginkgo Biloba Ekstresi insert ignore into journalissuearticles values(GBE); verilerek, bu ilaçların fonksiyonel iyileşme ve histo-patolojik değişiklikler üzerine etkileri araştırıldı. Toplam 50 tavşan beş gruba ayrıldı. 1.Gruba insert ignore into journalissuearticles values(10 tavşan); 500 jig/kg/7 gün süreyle Nimodipine intraperitoneal olarak verildi. 2.Gruba insert ignore into journalissuearticles values(10 tavşan); 2,5 |ig/kg/gün TRH intraperitoneal olarak verildi. 3. Gruba insert ignore into journalissuearticles values(10 tavşan); 1 mgr/kg/7 gün intraperitoneal olarak GBE verildi. 4. Gruba insert ignore into journalissuearticles values(10 tavşan); Nimodipine, TRH ve GBE aynı anda verildi. 5. Gruba insert ignore into journalissuearticles values(10 tavşan); hiçbir ilaç verilmedi. İlk üç grup arasında önemli bir klinik ve histopatolojik fark yoktu. 4. Grup klinik olarak diğerlerinden daha iyi idi.
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