Hematopoietik Büyüme Faktörleri

Authors : C DEMİRCAN, A FİSKECİ, İ YÜCEL

Pages : 0-0

Doi:10.5835/jecm.v11i2.530

View : 25 | Download : 15

Publication Date : 2009-12-22

Article Type : Other Papers

Abstract :Hematopoietic Growth Factors %/ Hematopoietic growuth factors insert ignore into journalissuearticles values(HGFs); are different glycoproteins which regulate hemato-poiesis, proliferation and differentiation of hematopoietic progenitor cells. Purified human recombinant HGFs are called colony stimulating factors insert ignore into journalissuearticles values(CSFs);. CSF stimulates the matu-ration of blood cells from colony forming unit insert ignore into journalissuearticles values(CFU);. The molecular physiology of CSF hasn`t been completely understood yet. The most important HGFs are granulocyte colony stimulating factor insert ignore into journalissuearticles values(G-CSF);, granulocyte-macrophage colony stimulating factor insert ignore into journalissuearticles values(GM-CSF);, interleukin-3, macrophage colony stimulating factor insert ignore into journalissuearticles values(M-CSF);, stem cell factor insert ignore into journalissuearticles values(SCF);, erythropoietin insert ignore into journalissuearticles values(EPO);, thrombopoietin insert ignore into journalissuearticles values(TPO); and other interleukins. Hematopoietik büyüme faktörleri insert ignore into journalissuearticles values(HGF);; hematopoiezisin regülasyonunu, hematopoietik progenitor hücrelerin çoğalmasını ve farklılaşmasını sağılayan çeşitli glikoproteinlerdir. Purifıye insan rekombinant HGF`lerine koloni stimule edici faktörler insert ignore into journalissuearticles values(CSF); denmektedir. CSF`ler koloni oluşturucu birimlerden insert ignore into journalissuearticles values(CFU); olgun kan hücrelerinin gelişimini uyarırlar. Ancak moleküler fizyolojileri henüz tam olarak anlaşılmış değildir. Başlıca HGFler; Granu-losit koloni stimule edici faktör insert ignore into journalissuearticles values(G-CSF);, Granülosit-makrofaj koloni stimule edici faktör insert ignore into journalissuearticles values(GM-CSF);, interleukin-3 insert ignore into journalissuearticles values(IL-3);, Makrofaj koloni stimule edici faktör insert ignore into journalissuearticles values(M-CSF);, Stem cell faktör insert ignore into journalissuearticles values(SCF);, Eritropoietin insert ignore into journalissuearticles values(EPO);, trombopoietin insert ignore into journalissuearticles values(TPO); ve diğer interluekinlerdir
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