Esansiyel Hipertansiyonlu Hastalarda Yavaş Salınımlı Diltiazem’in Sol Ventrikül Kitlesi Ve Diyastolik Fonksiyonlar Üzerindeki Etkisi

Authors : O YEŞİLDAĞ, E ÖRNEK, O SAĞKAN, M SHARİFİ MEHR, K DURNA

Pages : 0-0

Doi:10.5835/jecm.v12i3.623

View : 31 | Download : 11

Publication Date : 2009-12-23

Article Type : Other Papers

Abstract :The aim of this study was to examine the effects of a slow-release formulation of Diltia-zem-a calcium channel blorker-on blood pressure, left ventricular mass and diastolic functions in patients with essential hypertension. The study was carried out in 20 patients insert ignore into journalissuearticles values(10 female, 10 male); with a mean age of 53.9+2.2 [37-70] who had mild to moderate essential hypertension. A slow release formu¬lation of Diltiazem 120 mg was given once or twice a day for 3 months. Using M-mode, 2-D and pulsed Doppler echocardiography left verticular functions. Left venticular end-diastolic diameter, septal and posterior wall thickness, and, left venticular mass index were measured before and at the end of therapy. The results are as following; Blood pressure was decreased from 175.5+2.9/105.5±1.5 mmHg to 145.8+2.3987.8+1.4 after treatment for 3 months. Pulse rate was not altered. As a result of significant decrea¬ses in M-mode echocardiographic parameters such as left venticular end-diastolic diame¬ter; septal and posterior wall thickness [LVIDD insert ignore into journalissuearticles values(mm); 48.311.2^>46.0+1.1 LVST insert ignore into journalissuearticles values(mm); 12.3+0.4-^10.9+0.4, LVPWT insert ignore into journalissuearticles values(mm); 11.2+0.4^10.4+0.3] p 46.0+1.1, LVSTinsert ignore into journalissuearticles values(mm); 12.3+0.4-^10.9+0.4, LVPWT insert ignore into journalissuearticles values(mm); 11.2+0.4-^10.4+0.3] insert ignore into journalissuearticles values(p 0.8710.1 p<0.05);. Sonuç olarak yavaş salınımlı Diltiazem ile kan basıncında ve sol ventrikül kitle indeksinde önemli düşme olduğu, diyastolik fonksiyon parametrelerinden yalnızca E/A`da önemli bir iyileşme olduğu saptanmıştır.
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