Cis-Atrakuryum Ve Rokuronyum’un Entübsyon Koşulları Ve Hemodinami Üzerine Etkilerinin Karşılaştırılması

Authors : İs KOCAMANOĞLU, D KARAKAYA, , S BARIŞ, , B ŞENER, A TÜR

Pages : 0-0

Doi:10.5835/jecm.v19i4.223

View : 37 | Download : 7

Publication Date : 2009-12-23

Article Type : Other Papers

Abstract :Comparison of Effects of Cisatracurium and Rocuronium on Intubation Conditions and Hemodynamic Variables The aim of this study was to compare the intubation conditions, neuromuscular and hemodynamic effects with adverse effects of 3xED95 doses of cisatracurium and rocuronium. Fourty-nine patients insert ignore into journalissuearticles values(ASA I -11); undergoing elective operation were included in the study. Anesthesia was induced with propofol insert ignore into journalissuearticles values(2.5 mg/kg); and fentanyl insert ignore into journalissuearticles values(1 pg/kg);, and neuromuscular monitoring was established. Cisatracurium insert ignore into journalissuearticles values(0.15 mg/kg); were given group I insert ignore into journalissuearticles values(Group C, n=24);, and rocuronium insert ignore into journalissuearticles values(0.9 mg/kg); in group II insert ignore into journalissuearticles values(Group R, n=25);. Intubation of the trachea was performed, one and two minutes after muscle relaxants injection in Group R and Group C, respectively. Intubation scores, complications, heart rate insert ignore into journalissuearticles values(HR); and mean arterial blood pressure insert ignore into journalissuearticles values(MAP);, the times from injection of muscle relaxant to complete ablation of T, insert ignore into journalissuearticles values(onset time, T0);, from injection to recovery ofT, to 25% of baseline insert ignore into journalissuearticles values(clinical duration of action, T25); and to 75% of baseline insert ignore into journalissuearticles values(T75);, and recovery index insert ignore into journalissuearticles values(T25-T75); were recorded. Onset times for group R was significantly shorter Üian Group C insert ignore into journalissuearticles values(p 0.05);. Bronchospasm was developed in 2 patients insert ignore into journalissuearticles values(8%); in Group C. Spontaneous movements of hands associated with rocuronium administration were observed in 7 patients insert ignore into journalissuearticles values(28%); insert ignore into journalissuearticles values(p>0.05);. In conclusion the onset time of rocuronium was shorter, but cisatracurium provided a more stable hemodynamic parameters. However, rises in HR with rocuronium injection were within clinically acceptable values. Bu çalışmada 3xEDg5 dozlarında cis-atrakuryum ve rokuronyumun entübasyon koşullan, nöromüsküler ve hemodinamik etkileri ile yan etkilerinin karşılaştırılması amaçlandı. Elektif operasyon planlanan 49 erişkin hastaya insert ignore into journalissuearticles values(ASA I-II); propofol insert ignore into journalissuearticles values(2.5 mg/kg); ve fentanil insert ignore into journalissuearticles values(1 pg/kg); indüksiyonundan sonra nöromüsküler monitörizasyon yapıldı. Birinci gruba insert ignore into journalissuearticles values(Grup C, n=24); cis-atrakuryum insert ignore into journalissuearticles values(0.15 mg/kg);, ikinci gruba insert ignore into journalissuearticles values(Grup R, n=25); rokuronyum insert ignore into journalissuearticles values(0.9 mg/kg); 30 sn içinde verildi. Grup Cde 120 saniye insert ignore into journalissuearticles values(sn);, Grup R`de 60 sn sonra entübasyon denendi. Tekli uyarı cevabı insert ignore into journalissuearticles values(T,); 0 oluncaya kadar geçen süre insert ignore into journalissuearticles values(etki başlangıç süresi, T0);, T,`in başlangıç değerinin %25 insert ignore into journalissuearticles values(klinik etki süresi, T25); ve %75 insert ignore into journalissuearticles values(T75);`ine dönünceye kadar geçen süreler ve derlenme indeksi insert ignore into journalissuearticles values(T25-T75); kaydedildi. Entübasyon skorları, kalp atım hızları insert ignore into journalissuearticles values(KAH);, ortalama arter basınçları insert ignore into journalissuearticles values(OAB); ve komplikasyonlar kaydedildi. Etki başlama süresi Grup R`de daha kısa insert ignore into journalissuearticles values(p 0.05);. Cis-atrakuryum grubunda 2 insert ignore into journalissuearticles values(%8); hastada bronkospazm gelişti. Grup R`de 7 hastada insert ignore into journalissuearticles values(%28); ilaç enjeksiyonunu takiben spon-tan el çekme reaksiyonu görüldü insert ignore into journalissuearticles values(p>0.05);. Sonuç olarak rokuronyumun etki başlama süresi daha kısadır. Cis-atrakuryum ile daha sta-bil hemodinami sağlanmakla beraber rokuronyum kullanımında görülen KAH artışları klinik açıdan kabul edilebilir sınırlardadır.
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