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  • Journal of Experimental and Clinical Medicine
  • Volume:20 Issue:1
  • Kanser Kemoterapisi Ve Karaciğer

Kanser Kemoterapisi Ve Karaciğer

Authors : C ŞAHAN, , M ÖZTÜRK
Pages : 0-0
Doi:10.5835/jecm.v20i1.219
View : 27 | Download : 13
Publication Date : 2009-12-23
Article Type : Other Papers
Abstract :Cancer Chemotherapy and Liver The potential hepatotoxicity from cancer chemotherapy may be complex. Liver injury during cancer chemotherapy may not always reflect hepatotoxic anticancer drugs; the clinician must also consider reactions to antibiotics, analgesic, antiemetic other medications. Preexisting medical problems, tumor, immumosuppression, hepatitis viruses and other infections and nutrition deficiencies all may affect a host susceptibility to liver injury. Drugs that commonly produce hepatotoxicity are L-asparaginase, methotrexate, cytrabine, 6-thiopurines and mitramycin. The review discusses the effect of chemotherapeutic agents on the liver. Kanser kemoterapisinin potansiyel hepatotoksisltesl komplekstir. Kanser kemoterapisi sırasında karaciğer hasarı daima antikanser ilacın hepatotoksik etkisini yansıtmaz; klinisyen antibiyotik reaksiyonlannı, analjezikleri, antiemetikleri ve diğer ilaçlan düşünmek zorundadır. Daha öneki tıbbi problemler, tümör, immünosüpresyon, hepatit virüsleri ve diğer infeksiyonlar ve nütrisyonel eksiklikler konağın karaciğer hasanna yatkınlığını etkileyebilir. L-asparaginaz, methotreksat, sitarabin, 6-tiopürinler ve mitramisin yaygın olarak hepatotoksisiteye neden olan ilaçlardır. Bu derlemede kemoterapötik ajanlann karaciğer üzerine etkisi tarüşılmıştır.
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