Astrositik Neoplazilerde Fascin Ekspresyonu‡

Authors : Levent YILDIZ, Mehmet KEFELİ, Oğuz AYDIN, Bedri KANDEMİR

Pages : 45-49

Doi:10.5835/jecm.v25i2.1048

View : 50 | Download : 14

Publication Date : 2009-12-29

Article Type : Other Papers

Abstract :Fascin 55 kD ağırlığında aktin bağlayan bir proteindir. Hücre membranlarında bulunur ve hücresel motiliteyi başlatır. Fascin bazı malign tümörlerin biyolojik davranışı ile bağlantılıdır. Biz astrositom ve gliozis olgularında immünohistokimyasal olarak fascin ekspresyonunu araştırdık. İmmünohistokimyasal çalışma 28 astrositik tümör ve 6 gliozis olgusunda gerçekleştirildi. Glial hücreler ve tümör hücrelerinde fascin pozitifliği şu şekilde derecelendirildi; boyanma: %0-4 insert ignore into journalissuearticles values(-);, %5-25 insert ignore into journalissuearticles values(1+);, %26-50 insert ignore into journalissuearticles values(2+);, %51-75 insert ignore into journalissuearticles values(3+); ve %75’in üzeri 4insert ignore into journalissuearticles values(+);.Yirmi sekiz hastanın 17’si fascin pozitif boyandı insert ignore into journalissuearticles values(%60.7);. Yedi pilositik astrositom insert ignore into journalissuearticles values(WHO grade I); olgusunun 2’si insert ignore into journalissuearticles values(%28.5);, 6 diffüz astrositom insert ignore into journalissuearticles values(WHO grade II); olgusunun 4’ü insert ignore into journalissuearticles values(%66.6);, 8 anaplastik astrositom insert ignore into journalissuearticles values(WHO grade III); olgusunun 4’ü insert ignore into journalissuearticles values(%50); fascin pozitif boyandı. Glioblastom olgularının ise tamamı insert ignore into journalissuearticles values(7 olgu); insert ignore into journalissuearticles values(%100); fascin ile pozitif boyandı. Gliozis olgularının tamamında da insert ignore into journalissuearticles values(6 olgu); insert ignore into journalissuearticles values(%100); fascin boyanması gözlendi. Tümör grubunda 14 tümör olgusu 4 insert ignore into journalissuearticles values(+);, 3 tümör olgusu 3 insert ignore into journalissuearticles values(+); düzeyinde boyanma gösteriyordu. Karşılaştırıldığında 13 pilositik ve diffüz astrositom insert ignore into journalissuearticles values(WHO grade I ve II); olgusunun 6’sı insert ignore into journalissuearticles values(%46.1); fascin ile pozitif boyanma gösterirken, 15 anaplastik astrositom ve glioblastom insert ignore into journalissuearticles values(WHO grade III-I ve IV); olgusunun 11’inin insert ignore into journalissuearticles values(%73.3); fascin ile pozitif boyandığı gözlendi. Daha yüksek dereceli astrositomlar genel olarak daha yüksek derecelerde fascin boyanması gösterdiler. Astrositik tümörlerin malign biyolojik davranışında fascin ekspresyonu rol oynuyor olabilir. Fascin Expression in Astrocytic Neoplasms Fascin is a 55-kd actin binding protein. It is found in cell membranes and promoting cellular motility. Fascin has been linked to the malignant biological behavior of some tumors. We investigated immunuhistochemically fascin expression in astrocytomas and gliosis cases. Immunohistochemical study was performed in 28 astrocytic tumors and 6 gliosis. Fascin positivity of tumor cells and glial cells was graded as follows: Staining: 0% to 4%, insert ignore into journalissuearticles values(-);, 5% to 25%, insert ignore into journalissuearticles values(1+);, 26% to 50%, insert ignore into journalissuearticles values(2+);, 51% to 75%, insert ignore into journalissuearticles values(3+);, more than 75%, insert ignore into journalissuearticles values(4+);. Seventeen of 28 cases showed positive fascin staining insert ignore into journalissuearticles values(60.7%);. Two of 7 insert ignore into journalissuearticles values(28.5%); pilocytic astrocytoma insert ignore into journalissuearticles values(WHO grade I); cases, 4 of 6 insert ignore into journalissuearticles values(66.6%); diffuse astrocytoma insert ignore into journalissuearticles values(WHO grade II); cases and 4 of 8 insert ignore into journalissuearticles values(50%); anaplastic astrocytoma insert ignore into journalissuearticles values(WHO grade III); cases showed positive fascin staining. All of glioblastoma cases insert ignore into journalissuearticles values(7 cases); insert ignore into journalissuearticles values(100%); was positive. All of gliosis cases insert ignore into journalissuearticles values(6 cases); insert ignore into journalissuearticles values(100%); was positive. In tumor group, 14 tumors showed 4 insert ignore into journalissuearticles values(+); positive staining and 3 tumors had 3 insert ignore into journalissuearticles values(+); staining. In comparison, 6 of 13 pilocytic and diffuse astrocytoma insert ignore into journalissuearticles values(WHO grade I and II); cases had fascin positivity insert ignore into journalissuearticles values(46.1%);, 11 of 15 anaplastic astrocytoma and glioblastoma insert ignore into journalissuearticles values(WHO grade III and IV); cases had fascin positivity insert ignore into journalissuearticles values(73.3%);. Higher grade astrocytomas generally expressed a greater degree of fascin staining. Fascin expression may play a role in malignant biological behavior of astrocytic neoplasms.
Keywords :

ORIGINAL ARTICLE URL