Does Serotonin 2A Receptor Gene Polymorphism Increase The Vulnerability To Panic Attacks?

Authors : Lee Wei LİM, Koen SCHRUERS, Yasin TEMEL

Pages : 0-0

Doi:10.5835/jecm.v27i1.1374

View : 51 | Download : 11

Publication Date : 2012-01-25

Article Type : Other Papers

Abstract :Many studies have been conducted to show the genetic associations between the serotonin 2A receptor insert ignore into journalissuearticles values(HTR2A); gene polymorphisms and panic disorder insert ignore into journalissuearticles values(PD);, but the overall results are inconsistent and replication proved difficult. Here, we provide a concise overview of recent findings on genetic association studies with PD, which are summarized in a table. It has been shown that the HTR2A receptor gene 102T-C polymorphism is associated with a pure phenotype, and with agoraphobia in PD patients, and with panic-flight behaviour in healthy volunteers. Furthermore, the polymorphism is quantitatively correlated with panic symptoms severity. Interestingly, a role for this HTR2A 102T-C polymorphism was not found in less well-delineated samples of PD patients, also suffering from co-morbid conditions, nor in PD patients without agoraphobic symptoms. However, the majority of the studies had low sample sizes, and therefore there is a need for a well-designed study with a sufficient statistical power. The genetic association of HTR2A 102T-C polymorphism with PD insert ignore into journalissuearticles values(related to agoraphobia or panic symptom severity); provides entry points for new studies on molecular mechanisms in PD.
Keywords : panic disorder, serotonin 2A receptor, gene polymorphism

ORIGINAL ARTICLE URL