Effect of Postmenopausal Hormone Treatment on Serum Lipid Profile and Coagulation Factors

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Journal of Experimental and Clinical Medicine
Volume:27 Issue:3
Effect of Postmenopausal Hormone Treatment on Serum Lipid Profile and Coagulation Factors

Effect of Postmenopausal Hormone Treatment on Serum Lipid Profile and Coagulation Factors

Authors : Sinem BEDEN

Pages : 99-103

View : 31 | Download : 7

Publication Date : 2011-02-09

Article Type : Research Paper

Abstract :Background & Objectives: To assess the effects of different hormone treatment regimes on blood lipids, lipoproteins, ATIII, fibrinogen in postmenopausal patients. Methods: We studied retrospectively 115 patients who recieved one of four different estrogen treatment protocols. Of the 115 patiens; 25 had received transdermal estradiol patch 3.9 mg/weekinsert ignore into journalissuearticles values(TD); insert ignore into journalissuearticles values(Group-1);, 22 patients had received TD + MPA 2.5 insert ignore into journalissuearticles values(Group-2);, 19 patients had received oral CEE 0.625 mg/day insert ignore into journalissuearticles values(Group-3);, 23 patients had received CEE 0.625 mg/day + MPA 2.5 mg/day insert ignore into journalissuearticles values(Group-4);, 26 postmenopausal patients who had no hormonal treatment composed control group. Plasma cholesterol, lipids, lipoproteins, ATIII, and fibrinogen levels before and 6 months after treatment were checked from their recordings retrospectively. Results: Serum cholesterol level increased in control group, decreased in MPA taking Group-2, and Group-4. Serum LDL level decreased significantly in Group 2, 3, and 4 while it increased insignificantly in control group. Serum HDL level increased significantly only in oral CEE taking Group-3 insert ignore into journalissuearticles values(24% increase);. Trigliseride level significantly decreased in Group-2 insert ignore into journalissuearticles values(10.1% decrease);. Fibrinogen decreased in all treatment groups, ATIII did not change in treatment groups but increased in control group by 22.9%. Interpretation and Conclusion: Estrogen alone or in combination with progestin effects plasma lipid levels in a positive way. It also decreases fibrinogen level that might be protective for CVD.
Keywords : Key words Hormone replacement treatment, Menopause, Lipid profile, Coagulation factor

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