The effect of intravitreal ranibizumab injection on visual acuity and central macular thickness in subgroups with neovascular age-related macular degeneration

Authors : Ebru CÖMERT, Hakkı BİRİNCİ, Yüksel SÜLLÜ
Pages : 1-3
Doi:10.5835/jecm.omu.30.01.001
View : 47 | Download : 11
Publication Date : 2013-03-26
Article Type : Research Paper
Abstract :In this study, we assessed the effect of at least three intraocular ranibizumab injections, which were performed for the treatment of subfoveal choroidal neovascularization insert ignore into journalissuearticles values(CNV); secondary to neovascular age related macular degeneration insert ignore into journalissuearticles values(AMD);, on best corrected visual acuity insert ignore into journalissuearticles values(VA); and central macular thickness insert ignore into journalissuearticles values(CMT); in 89 patients who were classified by the component of lesion. Flouroscein angiography was performed and CNV have been classified in classic, occult or mixt insert ignore into journalissuearticles values(classic+occult); type. Best corrected VA was measured by Snellen card and was recorded in logMAR-logarithm of the minimum angle of resolution values. CMT was measured by optical coherence tomography. While CMT decreased significantly in patients with classic, mixt or occult type lesion insert ignore into journalissuearticles values(p=0.000; 0.011; 0.004, respectively);, the increase in VA was detected only in patients with classic type lesion insert ignore into journalissuearticles values(p=0.001);. A positive significant correlation between the decrease in CMT and the decrease in VA insert ignore into journalissuearticles values(logMAR); was reported only in the patients with occult type lesion insert ignore into journalissuearticles values(p=0.03);. In conclusion, the anatomical improvement, that is seen as a result of the treatment of AMD with intravitreal ranibizumab injection, is not associated with the increase in visual acuity in all types of CNV. 
Keywords : Age related macular degeneration, Central macular thickness, Choroidal neovascularization, Ranibizumab, Visual acuity

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