Comparison of maternal serum and umbilical cord concentrations of nitric oxide and asymmetric-dimethyl-arginine in pre-eclamptic and uncomplicated pregnancies

Authors : Mustafa ALBAYRAK, Mahmut ÖNCÜL, Seyfettin ULUDAĞ, Hafize UZUN, Ali BENİAN, Onur GÜRALP, Rıza MADAZLI
Pages : 125-128
Doi:10.5835/jecm.omu.30.02.007
View : 43 | Download : 14
Publication Date : 2013-07-31
Article Type : Other Papers
Abstract :The aim of this study was to compare maternal serum and umbilical cord levels of asymmetric-dimethyl-arginine insert ignore into journalissuearticles values(ADMA); and nitric oxide insert ignore into journalissuearticles values(NO); in pre-eclamptic and non-pre-eclamptic women and the possible effects of ADMA and NO on fetal outcome. Mean umbilical cord and maternal serum NO and ADMA levels of 29 women with preeclampsia insert ignore into journalissuearticles values(PE); and 24 randomly selected healthy pregnant women were compared. Maternal venous blood samples were collected before delivery and umbilical cord venous blood samples were obtained after delivery. Birth weight, apgar score, cord blood pH, duration of stay in the neonatal intensive care unit insert ignore into journalissuearticles values(NICU);, and maternal and neonatal complications were recorded. Umbilical cord ADMA and maternal NO levels were significantly higher in women with pre-eclampsia compared to women without pre-eclampsia. There were no significant differences between means of maternal serum ADMA levels and cord blood NO levels in women with and without pre-eclampsia. Maternal and cord serum NO and ADMA levels in the pre-eclampsia group did not show a significant correlation with cord blood pH, umbilical artery pulsatility index insert ignore into journalissuearticles values(PI);. In conclusion, umbilical cord ADMA and maternal NO levels were significantly higher in women with pre-eclampsia compared to women without pre-eclampsia.
Keywords : Asymmetric dimethyl arginine, cord blood, maternal serum, nitric oxide, pre eclampsia

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