Evaluation of serum thiol levels in patients with non ST elevation acute coronary syndrome

Authors : Fatih TANRIVERDİ, Havva KAVAKLI, Gülhan KURTOĞLU ÇELİK, Ferhat İÇME, Alp ŞENER, Onur KARAKAYALI, Sevilay VURAL

Pages : 295-299

Doi:10.5835/jecm.omu.30.04.003

View : 37 | Download : 9

Publication Date : 2014-02-04

Article Type : Research Paper

Abstract :Imbalance between antioxidant and oxidant systems in the body play an important role in the pathogenesis of coronary atherosclerosis and its complications. The aim of this clinical study was to investigate total serum thiol insert ignore into journalissuearticles values(TS-H); levels in patients with non ST Elevation Acute Coronary Syndrome insert ignore into journalissuearticles values(NSTE-ACS); patients and relationships between these results and cardiac markers. This study included 55 patients and a control group consisted of 50 healthy people. Samples for serum total TS-H levels were obtained from the patients considered with NSTE-ACS at the time of admission to emergency department. The patient group was divided into two subgroups according to troponin levels; that is patients with positive troponin levels in the non-ST-elevation myocardial infarction insert ignore into journalissuearticles values(NSTEMI); group and, and patients with negative troponin levels in the unstable angina pectoris insert ignore into journalissuearticles values(USAP); group. SPSS for Windows Ver. 15.0 software packages were used for statistical analysis of data in patient and control groups. The patients group included a total of 55 patients with 40 men insert ignore into journalissuearticles values(72.7%); and 15 women insert ignore into journalissuearticles values(27.3%); and the control group included 50 healthy individuals people with 28 men insert ignore into journalissuearticles values(56%); and 22 women insert ignore into journalissuearticles values(44%);. Total serum TS-H values were significantly lower in patients group when compared with the control group. Serum total TS-H values were significantly lower in USAP subgroup when compared with patients with NSTEMI. In addition, negative correlations between total serum TS-H values and troponin I and CK-MB were found. According to this study, total serum levels of thiol which is antioxidant marker TS-H may be useful as a confirming test in diagnosis of patients with NSTE-ACS and in differentiating patients with NSTEMI and USAP. 
Keywords : Acute coronary syndrome, Angina pectoris, Oxidative stress, Thiol

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