The effect of the antioxidant drug “U-74389G” on alkaline phosphatase levels during ischemia reperfusion injury in rats

Authors : Constantinos TSOMPOS, Constantinos PANOULİS, Konstantinos TOUTOUZAS, George ZOGRAFOS, Apostolos PAPALOİS
Pages : 0-0
Doi:10.5835/jecm.v2i31.5000011860
View : 38 | Download : 15
Publication Date : 2014-09-10
Article Type : Other Papers
Abstract :The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in a liver ischemia reperfusion insert ignore into journalissuearticles values(IR); protocol. The beneficial effect or non effectiveness of that molecule were studied biochemically using mean blood alkaline phosphatase levels insert ignore into journalissuearticles values(ALP);. Forty rats of mean weight 231.875 gr were used in the study. ALP levels were measured 60 min after reperfusion insert ignore into journalissuearticles values(groups A and C); and 120 min after reperfusion insert ignore into journalissuearticles values(groups B and D); with administration of the drug U-74389G in groups C and D. U-74389G administration non significantly increased the ALP levels by 19.76%±15.06% insert ignore into journalissuearticles values(p=0.1784);, but by 31.91%±7.69% insert ignore into journalissuearticles values(p=0.0001); for predicted values. Reperfusion time non-significantly decreased the ALP levels by 25.21%±14.83% insert ignore into journalissuearticles values(p=0.0675);, also by 6.38%±9.30% insert ignore into journalissuearticles values(p=0.3650); for predicted values. However, U-74389G administration and reperfusion time together non-significantly increased the ALP levels by 8.08%±9.19% insert ignore into journalissuearticles values(p=0.3696);, but also by 17.75%±4.79% insert ignore into journalissuearticles values(p=0.0005); for predicted values. This study indicates that U-74389G administration and its interaction with reperfusion time non significantly increased short-term effects on ALP levels. However, the predicted ALP values adjusted for rats weight, kept significantly increased ones, which stand for the restorating effects of U-74389G, that are slower than it seems.
Keywords : Alkaline phosphatase levels, ischemia, reperfusion, U 74389G

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