Volume fraction of the cerebellum in patients with Parkinson Disease

Authors : Bunyamin SAHIN, Emrah ALTUNSOY, Fikri OZDEMIR, Amani ELFAKI, Ilkay CAMLIDAG, Melten ACAR GUDEK

Pages : 0-0

Doi:10.5835/jecm.v2i31.5000068753

View : 47 | Download : 9

Publication Date : 2014-09-10

Article Type : Other Papers

Abstract :  Parkinson’s disease insert ignore into journalissuearticles values(PD); is a chronic progressive neurodegenerative disorder, leads to resting tremor, stiffness, slowness and impaired balance. Most investigations on PD focused on the basal ganglia and brainstem, whereas the cerebellum has often been overlooked. Therefore, the aim of this study was determined to describe and compare the cerebral volume and the cerebellar volume and volume fraction in Parkinson’s patients comparing with controls. In the present study, the total of 37 subjects, 19 control insert ignore into journalissuearticles values(9 female, 10 male); and 18 Parkinson’s patients insert ignore into journalissuearticles values(8 female, 10 male); were participated. The mean ages of males and females were 54.89, 55.5 and 54.5, 59.2 years-old in controls and patients, respectively. Structural magnetic resonance imaging insert ignore into journalissuearticles values(MRI); was done to both groups using SIEMENS 1.5 Tesla scanner. The images were analyzed using the ImageJ software. Volume and volume fractions were estimated using the planimetry methods of the stereological techniques. The mean total cerebral volumes were 943.19 cm 3 and  909.83 cm 3 in control and patient groups, respectively. Even the volumes of the controls were larger than the patients group it did not reached to a statistically significant level insert ignore into journalissuearticles values(p≥0.05);. The mean total cerebellar volume and volume fraction were 140.44 cm 3 , 14.94% in control and 140.51 cm 3 15.52% in patients groups, respectively. No statistically significant differences were observed between the groups insert ignore into journalissuearticles values(p≥0.05);.The findings showed that there was no statistical significant difference between control and patient. There are still controversial opinions about whether the cerebellar volume is affected in PD or not. Our knowledge about cerebellum and PD interaction remains limited, although, the cerebellum is a potential target for symptoms of the PD. Further investigations are needed with higher number of subjects in the groups to understand the changes of the cerebellum in PD.
Keywords : Cerebellum, magnetic resonance, Parkinsons disease, planimetry, volume fraction

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