Evaluating ESWL related alterations in renal pelvis and proximal ureter by analayting of tissue hydroxyproline levels

Authors : Mine ŞENYÜCEL, Özlem BOYBEYİ, Mustafa ASLAN, Tutku SOYER, Mahi BALCI, Arkut DEMET, Ücler KISA, Murad BAŞAR, Murat ÇAKMAK

Pages : 31-34

View : 50 | Download : 11

Publication Date : 2015-04-24

Article Type : Research Paper

Abstract :The aim of the study is to evaluate extracorporeal shock wave lithotripsy insert ignore into journalissuearticles values(ESWL); related alterations in renal pelvis and proximal ureter by using histopathological methods and analayting hydroxy-proline levels. Twelve New-Zealand rabbits were allocated into two groups insert ignore into journalissuearticles values(n=6);. Right sites of control group insert ignore into journalissuearticles values(CG, n=6); were harvested without any intervention. In ESWL group insert ignore into journalissuearticles values(EG);, right kidneys of subjects were exposed to 3000 shock waves insert ignore into journalissuearticles values(14 kV); by using electro-hydraulic type ESWL device three times. Rabbits in EG were sacrificed on day 7. Tissues were examined histopathologically for presence of edema, inflammation, congestion, hemorrhage, fibrosis, vascularization and biochemically for hydroxyproline concentrations. Histopathologically, tissue edema was increased in renal pelvises and inflammation was increased in ureters in the EG compared to that in the CG insert ignore into journalissuearticles values(p<0.5);. There was no difference in other parameters between the groups insert ignore into journalissuearticles values(p>0.05);. Tissue collagen density did not show any significant difference insert ignore into journalissuearticles values(p>0.05);. There was no difference in the tissue hydroxyl-proline levels of ureter samples insert ignore into journalissuearticles values(p>0.05);. Tissue hydroxyproline levels were significantly higher in EG than CG in renal pelvis insert ignore into journalissuearticles values(p<0.05);. In conclusion, although no major histopathological alteration due to ESWL was detected in renal pelvis and proximal ureter, increased hydroxyproline levels in the renal pelvis can be suggested as a finding of tissue injury in collecting system.
Keywords : Collecting system, ESWL, Hydroxyproline, Renal pelvis, Ureter

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