The relation among to mortality rate, hospitalization period and inflammatory mediators in patients with chronic obstructive pulmonary disease attack on admission to emergency department

Authors : Aysegül BAYIR, Pinar BUYUKUNALDI, Aysel KIYICI, Hasan KARA

Pages : 97-101

View : 46 | Download : 10

Publication Date : 2015-11-17

Article Type : Research Paper

Abstract :Chronic obstructive pulmonary disease insert ignore into journalissuearticles values(COPD); is characterized by a progressive and not completely reversible obstruction of the airways associated with an abnormal inflammatory response of the lungs to particles and noxious gases related to a systemic effect. Inflammatory processes are suggested to be involved in pathogenesis of COPD. The aim of the study was to investigate the relation among to the mortality rate, hospitalization period and inflammatory mediators of the patients with COPD attack on admission into the emergency department. A total of 87 subjects with COPD attack were contributed in this study. TNF-α, IL-6 and catalase were determined in addition to leucocyte count insert ignore into journalissuearticles values(WBC);, erythrocyte sedimentation rate insert ignore into journalissuearticles values(ESR); and C-reactive protein insert ignore into journalissuearticles values(CRP);. There was no significant difference between the deceased and discharged patients in terms of WBC, ESR, CRP, IL-6, and TNF-α. However, mean catalase levels of discharged patients were significantly higher than the deceased patients insert ignore into journalissuearticles values(p<0.05);. Significant correlations were observed between WBC and hospitalization period, and CRP and follow up period in the intensive care unit. We can suggest that catalase activities on admission into the emergency service were decreased in deceased patients who were in follow up in intensive care unit with COPD attack. High CRP and WBC levels were also related with the hospitalization period of patients with COPD attack. 
Keywords : Chronic obstructive pulmonary disease, Hospitalization, Inflammatory mediator, Mortality rate

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