Galectin-3 as a novel biomarker for the diagnosis of essential hypertension with left ventricular hypertrophy

Authors : Gokay NAR, Gokhan AKSAN, Ozkan GORGULU, Sinan INCİ, Korhan SOYLU, Metin OZDEMİR, Rukiye NAR, Serkan YÜKSEL, Mahmut SAHİN

Pages : 123-128

View : 44 | Download : 12

Publication Date : 2017-01-06

Article Type : Research Paper

Abstract :Galectin-3 insert ignore into journalissuearticles values(Gal-3); is a carbohydrate-binding protein that has important regulatory roles in inflammation, immunity and cancer. The aim of this study was to investigate the relationship of Gal-3 level with left ventricular hypertrophy insert ignore into journalissuearticles values(LVH); related to hypertension insert ignore into journalissuearticles values(HT);. Thirty seven patients insert ignore into journalissuearticles values(Group I); with newly diagnosed hypertension insert ignore into journalissuearticles values(HT); and left ventricular hypertrophy insert ignore into journalissuearticles values(LVH);were included in the study. Thirty eight patients with newly diagnosed hypertension without LVH insert ignore into journalissuearticles values(Group II); and 38 normotensive healthy volunteers insert ignore into journalissuearticles values(Group III); were included in the study as control group. Transthoracic echocardiography was performed and Gal-3 was measured in all patients.Although demographic characteristics of the groups were similar, systolic and diastolic blood pressure levels of Group I and Group II were significantly higher than Group III insert ignore into journalissuearticles values(p<0.001);. Interventricular septum insert ignore into journalissuearticles values(IVS); thickness, posterior wall insert ignore into journalissuearticles values(PW); thickness and left ventricular mass index insert ignore into journalissuearticles values(LVMI); were also significantly increased in Group I compared to Group II and Group III. Serum Gal-3 levels in all three groups were seen to be different from each other insert ignore into journalissuearticles values(p<0.001);. Increase of Gal-3 levels has a significant correlation with LVMI, IVS and PW thickness insert ignore into journalissuearticles values(p<0.001);.We determined that Gal-3 levels, even at the newly diagnosed stage of HT,were increased. Moreover, we found strong correlation between Gal-3 levels and left ventricular muscle mass. These results may indicate that increased Gal-3 level is an important marker for target organ damage and high cardiovascular risk in patients with HT. 
Keywords : Galectin 3, Hypertension, Left ventricular hypertrophy, Left ventricular muscle mass

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