Alternative method in experimental ERG for retinal toxicity

Authors : Volkan YETER, Osman SAYIN, Yüksel SÜLLÜ

Pages : 35-39

View : 60 | Download : 10

Publication Date : 2019-10-25

Article Type : Research Paper

Abstract :We aimed to define a cost-effective and alternative method for experimental electroretinography insert ignore into journalissuearticles values(ERG); in rabbits. The trigger input port of data acquisition device was connected to output port of an unemployed EEG device. The exposure area of photic stimulator was firmly covered by Wratten neutral density filters with variable optical densitiesinsert ignore into journalissuearticles values(ODs);. Different optical transmissions were obtained by putting more than one filter over the other one. The illumination of the area at the level of rabbit eye was measured by a luminometer in photic stimulations. ERG was performed to the both eyes of three albino rabbits in scotopic and photopic conditions at the baseline. Intravitreal saline injections were performed in right eyes of the rabbits. ERG and ophthalmologic examination were repeated one week later. ERG responses were obtained by short-duration light stimuli with different strengths in scotopic insert ignore into journalissuearticles values(-2.69; -1.69; 0.00; 0.30; 0.69; 0.90; 1.10; 1.30; 1.69; 2.00 log stimulus energy insert ignore into journalissuearticles values(log cd.s/m²);); and in photopic conditions insert ignore into journalissuearticles values(1.3; 1.69; 2.0; 2.10; 2.30 log stimulus energy insert ignore into journalissuearticles values(log cd.s/m²););. Although minimal decays in amplitudes of a- and b- waves were detected after saline injection, there was no significant difference between baseline and after injection for the stimulus-response time of a- and b- waves insert ignore into journalissuearticles values(p>0.05);. An unemployed EEG device can be effectively used for photic stimulation in experimental ERG in the studies of retinal toxicity.
Keywords : Electroretinography, photic stimulator, electroencephelography

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