The effect of intravenous N-acetyl cysteine on the incidence of postoperative atrial fibrillation in coronary artery bypass graft surgery patients

Authors : Elif COŞKUN SUNGUR, Levent ALTINAY, Mustafa BUYUKATES

Pages : 81-85

View : 50 | Download : 9

Publication Date : 2020-02-10

Article Type : Research Paper

Abstract :Atrial fibrillation is the most frequent arrhythmia after open heart surgery. The aim of this study was to determine the effect of intravenous insert ignore into journalissuearticles values(IV); N-acetyl cys-teine insert ignore into journalissuearticles values(NAC); administration in the early postoperative period of coronary ar-tery bypass insert ignore into journalissuearticles values(CABG); surgery on the incidence of postoperative atrial fibrillation insert ignore into journalissuearticles values(POAF);. A total of 60 patients who had undergone isolated CABG surgery be-tween June 2014 – July 2015 in our clinic included in this retrospective study. The patients divided into two groups: Group 1 insert ignore into journalissuearticles values(n=30); included the patients who had been administered standard saline solution infusion and Group 2 insert ignore into journalissuearticles values(n=30); included the patients who had been administered IV NAC insert ignore into journalissuearticles values(10mg/kg); infusion while they were under mechanical ventilation support. All patients were ad-ministrated oral 600 mg NAC once a day for 5 days after weaning from me-chanical ventilation support. The ECG’s were evaluated for POAF by the same cardiovascular surgeon who was blinded for patient groups. POAF was seen in 12 insert ignore into journalissuearticles values(40%); patients in Group 1 and 4 insert ignore into journalissuearticles values(13%); patients in Group 2. The POAF incidence was significantly higher in Group 1 insert ignore into journalissuearticles values(p=0.020);. We think that admin-istration IV NAC is an effective way to prevent the POAF after CABG surgery.
Keywords : Postoperative atrial fibrillation, coronary artery bypass surgery, n acetyl cysteine

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