Protective Effects Of Trimetazidine Against Hepatic Warm Ischemia/Reperfusion Injury On Rats

Authors : Sertaç AYHAN, Tevfik NOYAN, Sevil IŞIK, Sibel KÖKTÜRK

Pages : 66-71

View : 42 | Download : 8

Publication Date : 2021-04-03

Article Type : Research Paper

Abstract :Background/Aims: Nonalcoholic fatty liver disease insert ignore into journalissuearticles values(NAFLD); represents a spectrum of liver diseases that occur in individuals who do not consume a significant amount of alcohol, and the pathogenesis of NAFLD remains undefined. It was aimed to investigate whether the use of Trimetazidine insert ignore into journalissuearticles values(TMZ); could reduce warm ischemia-reperfusion insert ignore into journalissuearticles values(I/R); damage after liver ischemia on an experimental NAFLD model in this experimental study. Methods: For this aim, Sprague Dawley male rats were separated into 4 groups; control group insert ignore into journalissuearticles values(group 1, n = 6);, sham operated control grup insert ignore into journalissuearticles values(group 2, n = 6);, warm ischemia/reperfusion group insert ignore into journalissuearticles values(group 3, n=10);, and TMZ group insert ignore into journalissuearticles values(group 4, n=10, administration of TMZ insert ignore into journalissuearticles values(10 mg/kg); 30-min before fatty liver I/R);. The serum oxidant and antioxidant biochemical markers were measured by ELISA methods. The histopathological evaluation was also performed in the hepatocytes. Results: TMZ was caused to significantly decrease on oxidative stress markers levels which characterized myeloperoxidase insert ignore into journalissuearticles values(MPO); insert ignore into journalissuearticles values(p 0.05);. While hepatocyte damage as a form of cell groups was observed due to I/R damage, whereas TMZ had caused positive improvements on dilatation of sinusoids, inflammation and the structural integrity of hepatic plaques. Conclusion: Trimetazidine could be positively contributing effects to the antioxidant defense mechanism and also the survival of cells by protecting mitochondrial integrity.
Keywords : Warm Ischemia, Reperfusion Injury, Non alcoholic Fatty Liver Disease, Oxidative Stress, Trimetazidine

ORIGINAL ARTICLE URL