Volumetric Analysis of the Brain Structures of Children with Down’s Syndrome: A 3D MRI Study

Authors : Fatma ÖZ, Niyazi ACER, Yasin CEVİZ, Recep ERÖZ, Halit CANATAN, Bircan YUCEKAYA

Pages : 197-203

View : 57 | Download : 11

Publication Date : 2021-04-03

Article Type : Research Paper

Abstract :Introduction: Down’s syndrome insert ignore into journalissuearticles values(DS); is one of the most common genetic causes of mental and cognitive retardation. In fact, it results in a number of characteristic neuropsychological and physical symptoms, including mental retardation. The aim of this study was to compare the brain structure volumes of children with DS to those of healthy children using MRI Studio in order to investigate whether there exists correlation between the developmental stages of DS and the results of both the Denver II Developmental Screening Test and magnetic resonance imaging insert ignore into journalissuearticles values(MRI); quantitative analysis. Method: Five children diagnosed with Down’s syndrome insert ignore into journalissuearticles values(age range = 2–6 years); were matched for gender and age with five healthy comparison subjects. To analyse the overall and regional brain volumes, high-resolution MRI scans were performed and a morphometric analysis was conducted via MRI Studio software. The MRI T1 volumetric images were normalised using a linear transformation, which was followed by large deformation diffeomorphic metric mapping. Results: Significant decreases insert ignore into journalissuearticles values(p 0.05);. It was further found that the developmental retardation observed in the children with DS, as detected using the Denver II test, increased due to decreases in the volumes of certain regions of the brain, although this was also not statistically significant insert ignore into journalissuearticles values(p > 0.05);. Conclusion: The results of this study generally confirm the findings of prior studies concerning the overall patterns of the brain volumes in childeren with DS and also provide new evidence of the abnormal volumes of specific regional tissue components among such a population. These results suggest that the brain volume reduction associated with DS may primarily be due to early developmental differences rather than neurodegenerative changes.
Keywords : Downs syndrome, brain volume, MRI, Denver II Test

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