Evaluation of metabolic and hormonal parameters in women with PCOS living in Black Sea Region

Authors : Nur DOKUZEYLÜL GÜNGÖR, Samettin ÇELİK, Mehmet GÜÇLÜ, Sebahattin ÇELİK, Ferhat CENGİZ

Pages : 235-240

View : 117 | Download : 9

Publication Date : 2021-05-01

Article Type : Research Paper

Abstract :Polycystic ovary syndromeinsert ignore into journalissuearticles values(PCOS); is the most common endocrinopathy which is frequently associated with metabolic syndrome. The aim of this study is to compare the clinical,biochemical and hormonal characteristics of healthy women and women with PCOS in Black Sea Region.91 healthy womeninsert ignore into journalissuearticles values(Group=1); and 109 PCOSinsert ignore into journalissuearticles values(Group=2); patients were included in this retrospective study. This study was conducted in Samsun Women and Children’s Health Research and Training Hospital between October 2019-May 2020.The anthropometric, clinical and laboratory characteristics of the women were recorded. The Institutional Review Board of the hospital approved the study. IBM SPSS Statistics 22 programme was used for statistical analysis. . Variables were expressed as mean ± standard deviation or as a number insert ignore into journalissuearticles values(percentage);, and statistical significance was defined as a p value of less than 0.05.In this study, no statistically significant difference was found between patients with PCOS and control subjects in age,height ,BMI, waist circumference and waist-to-hip ratio. Weight ,BP systolic,BP diastolic and FG scores, were significantly higher in patients with PCOS compared to control subjects.In this study,no statistically significant difference was found between patients with PCOS and control subjects in FSH, estradiol prolactin ,TSH,fT3,fT4 and DHEASO4 levels.But,LH, cortisol, total and free testesterone and 17-OH progesteron levels were significantly higher in patients with PCOS compared to control subjects.Also in this study, vitamin B12 and the 25-OH-D levels were significantly lower in patients with PCOS compared to control subjects.HbA1C,fasting blood glucose levels,fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS compared to control subjects . Total-C , LDL-C and TG levels were significantly higher in women with PCOS compared to control subjects.Also HDL-C levels were significantly lower in women with PCOS compared to control subjects.As a result, the risk of metabolic syndrome is increased in PCOS patients because of high androgen levels,obesity and insulin resistance.
Keywords : polycystic ovarian syndrome, metabolic syndrome, hormone profile, lipid profile

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