Effect of Routine Duloxetine Administration in the Early Postoperative Period on Post- Prostatectomy Stress Incontinence in Patients Undergoing Laparoscopic Radical Prostatectomy

Authors : Gökhan SÖNMEZ, Şevket Tolga TOMBUL, Deniz DEMİRCİ, Numan BAYDİLLİ, Türev DEMİRTAŞ, Serhan ARMAN, Abdullah DEMİRTAS

Pages : 336-339

View : 69 | Download : 8

Publication Date : 2021-05-01

Article Type : Research Paper

Abstract :Post-prostatectomy stress incontinence insert ignore into journalissuearticles values(PPI); is an important health problem for patients with radical prostatectomy history. Duloxetine is a common drug, used in PPI with the out of indications in most countries. In this study, we aimed to evaluate the prophylactic effect of duloxetine administration in PPI during the early postoperative period in patients undergoing laparoscopic radical prostatectomy insert ignore into journalissuearticles values(LRP);. The retrospective study included 209 patients who underwent LRP. Patients were divided into two groups: Group I insert ignore into journalissuearticles values(n=96); was initiated on pelvic floor exercises insert ignore into journalissuearticles values(PFE); + duloxetine in the early postoperative period and continued this regimen for a total of 12 weeks and Group II insert ignore into journalissuearticles values(n=113); only performed PFE for 12 weeks after surgery. Exclusion criteria were as follows: a history of neuromuscular dysfunction of bladder, post-prostatectomy urge incontinence, receiving adjuvant radiotherapy during the 12- week period, prior anti-incontinence surgery, and post-voiding urine>100 ml. The prevalence rates of urinary incontinence measured at the time of urinary catheter removal insert ignore into journalissuearticles values(baseline); and at weeks 3, 6, and 12 after surgery and the number of wet pads per day were compared. The study included 209 patients with a mean age of 60.68 ± 7.16 years. Baseline urinary continence rates were similar in Group I and Group II insert ignore into journalissuearticles values(29.2% vs. 35.4%, p=0.338);. At 12 weeks, although PPI rates have decreased in both groups, there was no difference between Group I and Group II insert ignore into journalissuearticles values(15.6% vs. 24.8%, p=0.103);. Administration of prophylactic duloxetine in the early postoperative period, which started without regard to the positivity of PPI, is not significantly effective to early postoperative urinary continence recovery.
Keywords : post prostatectomy incontinence, duloxetine, radical prostatectomy, prostate cancer

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