Histopathological effect of platelet-rich plasma on cranial dura mater defects

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Journal of Experimental and Clinical Medicine
Volume:38 Issue:4
Histopathological effect of platelet-rich plasma on cranial dura mater defects

Histopathological effect of platelet-rich plasma on cranial dura mater defects

Authors : Kemal PAKSOY, Kerameddin AYDIN

Pages : 525-528

View : 38 | Download : 11

Publication Date : 2021-10-09

Article Type : Research Paper

Abstract :Objective: There are many new studies in the selection of materials used in dura material repair. Platelet has important function in hemostasis and coagulation. Also, activated platelets initiate the wound healing process. They provide regeneration of tissue with the appropriate type of tissue. In this experimental study, we used platelet-rich plasma insert ignore into journalissuearticles values(PRP); on dura mater defect due to these properties. Materials and method: Our study started after we got the approval of Ondokuz Mayıs University Animal Experiments Local Ethics Committee.30 Wistar Albino female rats were used. The rats were divided into three groups, each one includes ten. Results: No significant difference was observed in the thickness and surface areas of dura mater in group 1 and group 2. Significant increase was observed in the thickness and surface areas of dura mater in the PRP applied group insert ignore into journalissuearticles values(Group 3); compared to other groups .New bone areas and new vasculature were observed more frequently in the PRP rooms group insert ignore into journalissuearticles values(Group 3);.Statistical analysis of the data was done by using SPSS 21.0 for Mac insert ignore into journalissuearticles values(IBM Corporation); statistical package program and based on 0.05 significance level.A significant difference was observed between Group 1 and Group 3 insert ignore into journalissuearticles values(p> 0.05);, a significant difference was observed between both Group 1 and Group 3 and between Group 2 and Group 3 insert ignore into journalissuearticles values(p <0.05);. Conclusion: Providing the regeneration of dura mater in defect situations will contribute to the protection of the barrier feature .In line with this idea, it is thought that PRP can be beneficial for us to reach this goal.
Keywords : Cranial Dura Mater, Histopathology, Platelet Rich Plasma

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