Hyperpigmentation-Ashy Dermatosis

Authors : Hanife Merve AKÇA, Zeynep BAYRAMOĞLU

Pages : 579-580

View : 69 | Download : 12

Publication Date : 2022-03-18

Article Type : Other Papers

Abstract :Erythema dyschromicum perstans insert ignore into journalissuearticles values(EDP);, also known as Ashy dermatosis, is a hypermelanotic condition characterized by the formation of a slate-gray macula in healthy individuals insert ignore into journalissuearticles values(1);. The disease, which does not cause any systemic involvement or any known internal organ involvement other than skin findings, creates cosmetic concerns due to its external appearance and requires treatmentinsert ignore into journalissuearticles values(2);. It is seen equally in men and women. insert ignore into journalissuearticles values(1,3);. Here, a case of sudden onset of EDP in a 19-year-old male patient is presented. A 19-year-old male patient presented with discoloration on the anterior and posterior trunks for three months that had increased in the last two weeks. In the dermatological examination; Pigmented macules and patches of different sizes, which tend to coalesce from place to place, were observed on the back and anterior aspect of the trunk insert ignore into journalissuearticles values(Picture 1); insert ignore into journalissuearticles values(Picture 2);. In the anamnesis, it was learned that the lesions were more erythematous and purplish at the beginning of her complaints. The patient`s lesions did not regress with local moderate potent coticosteroid treatment. There was no additional systemic disease or drug use in the patient, who had no different features in his or her history and family history. Laboratory tests of the patient were complete blood count, liver and kidney function tests, sedimentation rate, thyroid function tests, complete urine analysis were within normal limits, anti-HBs, anti- HCV, anti-HIV, VDRL and ANA tests were negative. In the histopathological examination of the biopsy taken from the lesions on the back and anterior surface of the trunk, the patient was diagnosed with EDP because of vacuolar degeneration in the basal layer, mild lymphohistiocytic inflammatory cell infiltration around the vessels in the upper dermis, melanophages and pigment incontinence, and a small amount of lymphocyte exocytosis in the epithelium insert ignore into journalissuearticles values(Picture 3);. . The patient, whose diagnosis of EDP was confirmed, was started on 100 mg/day dapsone treatment and the lesions were kept under control. Ashy dermatosis insert ignore into journalissuearticles values(EDP); is a rare dermal melanosis that was first described by Ramirez in 1957 and is in the class of acquired pigmentations. insert ignore into journalissuearticles values(4,5);. Although the cause is unknown, it has been stated that some factors may be responsible for the disease. infections insert ignore into journalissuearticles values(parasitic and HIV);, drugs insert ignore into journalissuearticles values(penicillins, ethambutol and benzodiazepines);, radiocontrast agents, ammonium nitrate, cobalt, fungicides. It is thought that conditions such as thyroid dysfunction and endocrinopathies such as diabetes mellitus, atopy and dyslipidemia may also be responsible for the picture. Immunopathological examinations of active lesions suggest that immune-mediated mechanisms may play a role in the pathogenesis of EDPinsert ignore into journalissuearticles values(5,6);. Hyperpigmentation indicates a condition that occurs with pigment deposition in the epidermis and/or dermis. Apart from EDP, many dermatological diseases such as postinflammatory hyperpigmentation insert ignore into journalissuearticles values(PIH);, primary cutaneous amyloidosis insert ignore into journalissuearticles values(PKA);, neuralgia paresthetica insert ignore into journalissuearticles values(NP); and some drug reactions are the cause of acquired hyperpigmentation in the body. may insert ignore into journalissuearticles values(7);. There are few studies on the treatment of EDP. While sun protection, chemical peeling agents, antibiotics, topical and systemic steroids have not been found effective in the treatment, partial response to agents such as griseofulvin, clofazimine and dapsone is mentioned insert ignore into journalissuearticles values(8);. EDP is known as a rare dermatosis. Differential diagnosis and treatment may be inadequate from time to time. Therefore, more clinical observations are needed to increase the diagnosis and treatment practice.
Keywords : Hyperpigmentation, Ashy Dermatosis, Dapsone

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