Structure and functions of spexin as a new neuroendocrine signal

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Journal of Experimental and Clinical Medicine
Volume:39 Issue:3
Structure and functions of spexin as a new neuroendocrine signal

Structure and functions of spexin as a new neuroendocrine signal

Authors : Özge DARAKCI, Ayhan BOZKURT

Pages : 893-900

View : 59 | Download : 8

Publication Date : 2022-08-30

Article Type : Review Paper

Abstract :Spexin insert ignore into journalissuearticles values(SPX ); s a recently discovered endogenous peptide consisting of 14 amino acids. It was found that SPX, kisspeptin insert ignore into journalissuearticles values(KISS);, and galanin insert ignore into journalissuearticles values(GAL); peptides belong to the same gene family and is also endogenous ligand of GAL2 and GAL3 receptors. The amino acid sequence of the SPX peptide is relatively conserved in vertebrates and invertebrates. The mRNA and protein of SPX are highly expressed both in peripheral organs and the peripheral/central nervous system of mammals, birds, and fishes. Many biological roles of SPX were found in non-mammal/mammals, including food intake, energy metabolism, reproduction, nociception, gastrointestinal motility, stress, and endocrine functions. This review collectively mentions the peptide structure of SPX, its receptors and distribution in tissues, and the biological activities of SPX on various organs.
Keywords : galanin 2 receptor, galanin 3 receptor, Neuropeptide, NPQ, spexin

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