Change in GFR in relation to pulse rate, dipping blood pressure, anti-hypertensives, NLR and PLR in patients with chronic kidney disease

Authors : Hüseyin DURU

Pages : 934-938

View : 28 | Download : 9

Publication Date : 2022-10-29

Article Type : Research Paper

Abstract :This study aimed to evaluate change in glomerular filtration rate insert ignore into journalissuearticles values(GFR); in chronic kidney disease insert ignore into journalissuearticles values(CKD); patients in relation to certain 24-h ambulatory blood pressure monitoring insert ignore into journalissuearticles values(ABPM); parameters, anti-hypertensives and inflammatory markers. A total of 206 adult CKD patients insert ignore into journalissuearticles values(mean±SD age: 51.3±17.1 years, 54.9% were females); were included in this retrospective study. Data on patient demographics, comorbidity and medications, 24-h ABPM parameters insert ignore into journalissuearticles values(pulse rate and dipping systolic and diastolic BP);, neutrophil-to-lymphocyte ratio insert ignore into journalissuearticles values(NLR);, platelet-to-lymphocyte ratio insert ignore into journalissuearticles values(PLR);and GFR were recorded. The change in e-GFR values from baseline was evaluated with respect to study variables. There was a mean -1.5 mL/min/1.73m2insert ignore into journalissuearticles values(range -80.2 to 18.1); decline from baseline GFR during study period. The decrease in GFR from baseline was significantly lower in patients with vs. without diuretic therapy insert ignore into journalissuearticles values(median 1.2 vs. 0 mL/min/1.73m2, p=0.017);. GFR change from baseline was positively correlated with patient age insert ignore into journalissuearticles values(r=0.145, p=0.040); as well as with the total insert ignore into journalissuearticles values(r=0.198, p=0.005);, day-time insert ignore into journalissuearticles values(r=0.184, p=0.009); and night-time insert ignore into journalissuearticles values(r=0.219, p=0.003); pulse rate. No significant difference was noted in GFR change from baseline with respect to gender, antihypertensive medications other than diuretics, the dipping systolic or diastolic BP values or inflammatory markers. Our findings revealed significant correlation of age, pulse rate and diuretic usage but not dipping systolic or diastolic BP or inflammatory markers with the GFR change from baseline.
Keywords : Chronic kidney disease, hypertension, renal progression, dipping blood pressure, antihypertensive medications, inflammatory markers

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