CRISPR/Cas9 system in hematopoietic stem cells: Basic research and clinical applications

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Journal of Experimental and Clinical Medicine
Volume:40 Issue:1
CRISPR/Cas9 system in hematopoietic stem cells: Basic research and clinical applications

CRISPR/Cas9 system in hematopoietic stem cells: Basic research and clinical applications

Authors : Esra ALBAYRAK

Pages : 161-170

View : 163 | Download : 175

Publication Date : 2023-03-18

Article Type : Review Paper

Abstract :Clustered regularly interspaced short palindromic repeats insert ignore into journalissuearticles values(CRISPR); approach adapted from the prokaryotic adaptive immune system against to pathogen attack is so valuable and promising tool for treatment of human malignant and non-malignant hematological disease and disorders through genome editing in hematopoietic stem cells insert ignore into journalissuearticles values(HSCs);. Moreover, CRISPR/Cas9 approach is not only useful for therapeutic purposes; it is considerably preferred for the generation of in vitro and in vivo animal disease models. CRISPR/Cas9 approach has been developed for highly efficient on-target cleavage, and low off-target effect via delivery systems and manipulation of CRISPR components including single guide RNA insert ignore into journalissuearticles values(sgRNA); and Cas enzymes. In this review, we focused on the CRISPR/Cas9 system applications on hematopoietic stem cells in basic research and clinical area with basic research and clinical perspectives.
Keywords : Hematopoietic stem cells, CRISPR Cas9, Gene editing, Genome engineering, Hematologic diseases, Hematologic malignancies

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